WormBase Tree Display for Gene: WBGene00004854

WBGene00004854 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: slt-1 Person_evidence: WBPerson42
      Sequence_name: F40E10.4
      Molecular_name: F40E10.4
        F40E10.4.1
        CE32412
      Other_name: CELE_F40E10.4 Accession_evidence: NDB BX284606
      Public_name: slt-1
    DB_info: Database: AceView gene XP301
        WormQTL gene WBGene00004854
        WormFlux gene WBGene00004854
        NDB locus_tag CELE_F40E10.4
        Panther gene CAEEL|WormBase=WBGene00004854|UniProtKB=G5EFX6
          family PTHR45836
        NCBI gene 181562
        RefSeq protein NM_078036.8
        SwissProt UniProtAcc G5EFX6
        TREEFAM TREEFAM_ID TF332887
        UniProt_GCRP UniProtAcc G5EFX6
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: slt
    Allele (191)
    Strain: WBStrain00034914
      WBStrain00005267
      WBStrain00005270
      WBStrain00005271
      WBStrain00005272
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog: WBGene00058536 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00029567 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00110130 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00191814 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00224221 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3017 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7993 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7978 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP31.g24983 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g10283 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g8746 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00273.g8272 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-slt-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10053 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00423.g11170 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01680 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_025657 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g4466 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0143410 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20628 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00082138 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00241739 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266449 Strongyloides ratti From_analysis: WormBase-Compara
      FB:FBgn0264089 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-010306-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010306-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030722-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030722-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:11085 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11087 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11086 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1315203 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1315205 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1315202 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:69307 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:69311 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:69310 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            PhylomeDB
    Paralog (4)
    Structured_description: Concise_description: slt-1 encodes the sole C. elegans homolog of Drosophila Split, a secreted extracellular protein containing leucine-rich and EGF-like repeats that functions as a ligand for the Robo receptor; during C. elegans larval development, slt-1 acts via the SAX-3/Robo receptor, and in parallel with UNC-6/Netrin, to direct ventral axon guidance and guidance at the midline; during embryonic development, slt-1 also functions to regulate anterior-posterior migrations of the CAN neurons; slt-1::gfp reporters are initially expressed at high levels in the anterior part of the embryo, with more moderate levels seen in dorsal tail muscles and lower levels seen in cells in the center of the body; in L1 larvae, slt-1::gfp is expressed in both dorsal and ventral muscles, with higher levels seen in dorsal muscle cells; slt-1::gfp is also expressed in a number of additional cells including some neurons, pharyngeal cells, and the anal sphincter muscle. Paper_evidence: WBPaper00004900
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jun 2007 00:00:00
      Automated_description: Enables signaling receptor binding activity. Involved in axon guidance; neuron migration; and regulation of neuron projection development. Predicted to be located in extracellular region. Expressed in anal sphincter muscle; anterior hypodermis; body wall musculature; nerve ring neurons; and socket cell. Human ortholog(s) of this gene implicated in atrial fibrillation; myositis (multiple); and proliferative diabetic retinopathy. Is an ortholog of human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:13207 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11086)
      DOID:0080745 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11086)
      DOID:10223 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11086)
      DOID:0060224 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11086)
  Molecular_info: Corresponding_CDS: F40E10.4
    Corresponding_CDS_history: F40E10.4:wp90
    Corresponding_transcript: F40E10.4.1
    Other_sequence (11)
    Associated_feature: WBsf648747
      WBsf648748
      WBsf663583
      WBsf663584
      WBsf663585
      WBsf717401
      WBsf236701
      WBsf236702
      WBsf236703
  Experimental_info: RNAi_result: WBRNAi00011228 Inferred_automatically: RNAi_primary
      WBRNAi00086123 Inferred_automatically: RNAi_primary
      WBRNAi00001158 Inferred_automatically: RNAi_primary
      WBRNAi00046840 Inferred_automatically: RNAi_primary
      WBRNAi00032019 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1639
      Expr8003
      Expr1016319
      Expr1032406
      Expr1150710
      Expr2015887
      Expr2034120
    Drives_construct: WBCnstr00000844
      WBCnstr00008334
      WBCnstr00013053
      WBCnstr00035356
      WBCnstr00038306
    Construct_product: WBCnstr00000848
      WBCnstr00000849
      WBCnstr00000851
      WBCnstr00000852
      WBCnstr00035356
    Microarray_results (20)
    Expression_cluster (176)
    Interaction (102)
  Map_info: Map: X Position: 19.7628 Error: 0.06206
    Positive: Positive_clone: F40E10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4664
        5528
    Pseudo_map_position
  Reference (74)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene