WormBase Tree Display for Gene: WBGene00009048

WBGene00009048 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: cth-1 Person_evidence: WBPerson1711
      Sequence_name: F22B8.6
      Molecular_name: F22B8.6a
        F22B8.6a.1
        CE15884
        F22B8.6b
        CE48039
        F22B8.6b.1
      Other_name: CELE_F22B8.6 Accession_evidence: NDB BX284605
      Public_name: cth-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 10 Sep 2008 16:37:04 WBPerson2970 Name_change: CGC_name: cth-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cth
    Allele (39)
    Strain: WBStrain00037414
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00042787 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00194401 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00152250 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00075890 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00054249 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00054295 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00109584 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227890 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g7404 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3578 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP28.g1263 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g17413 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g2108 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10009 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21350 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g7613 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      Cang_2012_03_13_00619.g12862 Caenorhabditis angaria From_analysis: WormBase-Compara
      Csp11.Scaffold589.g4993 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      FL83_09485 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_006452 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02192 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g18740 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g8649 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20264210 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g17038 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00121794 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00247861 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00273954 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256758 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00299309 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0000566 Drosophila melanogaster From_analysis: Panther
            PhylomeDB
            EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      SGD:S000000010 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-774 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040905-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2501 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1339968 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2443 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00007533 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022856 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: cth-1 encodes a putative cystathionine gamma-lyase; CTH-1 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog CTH-2, and also paralogous to CBL-1; either CTH-1, or CTH-2, or both proteins weakly inhibitDHC-1 in vivo. Paper_evidence: WBPaper00030897
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 15 Sep 2011 00:00:00
      Automated_description: Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in cystathioninuria. Is an ortholog of human CTH (cystathionine gamma-lyase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9252 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2501)
      DOID:0090142 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2501)
  Molecular_info: Corresponding_CDS: F22B8.6a
      F22B8.6b
    Corresponding_transcript: F22B8.6a.1
      F22B8.6b.1
    Other_sequence (27)
    Associated_feature: WBsf647621
      WBsf233073
      WBsf233074
      WBsf233075
  Experimental_info: RNAi_result: WBRNAi00013745 Inferred_automatically: RNAi_primary
      WBRNAi00076329 Inferred_automatically: RNAi_primary
      WBRNAi00045303 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1022511
      Expr1033944
      Expr1149227
      Expr2010573
      Expr2028813
    Microarray_results (24)
    Expression_cluster (296)
    Interaction (43)
  Map_info: Map: V Position: 9.56078 Error: 0.007504
    Positive: Positive_clone: F22B8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00040475
    WBPaper00055090
    WBPaper00059856
    WBPaper00062322
    WBPaper00062388
    WBPaper00062518
    WBPaper00064934
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene