WormBase Tree Display for Gene: WBGene00004357
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WBGene00004357 | SMap | S_parent | Sequence | Y51H4A | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | rho-1 | Person_evidence | WBPerson237 | |||||
Sequence_name | Y51H4A.3 | ||||||||
Molecular_name | Y51H4A.3a | ||||||||
Y51H4A.3a.1 | |||||||||
CE25369 | |||||||||
Y51H4A.3b | |||||||||
Other_name | RhoA | Accession_evidence | EMBL | L36965 | |||||
Y51H4A.B | Paper_evidence | WBPaper00004196 | |||||||
CELE_Y51H4A.3 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | rho-1 | ||||||||
DB_info | Database | AceView | gene | 4R428 | |||||
WormQTL | gene | WBGene00004357 | |||||||
WormFlux | gene | WBGene00004357 | |||||||
NDB | locus_tag | CELE_Y51H4A.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038 | |||||||
family | PTHR24072 | ||||||||
NCBI | gene | 178458 | |||||||
RefSeq | protein | NR_131670.1 | |||||||
NM_070558.9 | |||||||||
SwissProt | UniProtAcc | Q22038 | |||||||
UniProt_GCRP | UniProtAcc | Q22038 | |||||||
RNAcentral | URSid | URS00007B0C17 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | rho | ||||||||
Allele (155) | |||||||||
Strain | WBStrain00036907 | ||||||||
WBStrain00047246 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (40) | |||||||||
Ortholog (58) | |||||||||
Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00012532 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | rho-1 encodes a Rho GTPase; rho-1 activity is required for regulation of a number of actin filament-based processes including embryonic polarity, cell migration, cell shape changes, muscle contraction, and neurite outgrowth; in addition, RHO-1 is required for both DGK-1- and UNC-13-dependent and independent regulation of synaptic signaling at neuromuscular junctions; as RHO-1 binds DGK-1 in vitro, its regulation of DGK-1-mediated signaling may be direct; in vitro RHO-1 GTPase activity is enhanced by the RGA-3 and RGA-4 GAP proteins, consistent with genetic studies showing that, in the early embryo, RHO-1 activity is required for expression of the rga-3/4(RNAi) hypercontractibility phenotype; RHO-1 is ubiquitously expressed throughout development with notably high expression seen in head neurons and asymmetric expression seen in the anterior cortex of one-cell embryos. | Paper_evidence | WBPaper00002066 | |||||
WBPaper00004340 | |||||||||
WBPaper00004959 | |||||||||
WBPaper00013415 | |||||||||
WBPaper00027016 | |||||||||
WBPaper00028358 | |||||||||
WBPaper00028408 | |||||||||
WBPaper00031005 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 13 Sep 2007 00:00:00 | ||||||||
Automated_description | Enables several functions, including GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion. Located in cell cortex and cleavage furrow. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; multiple sclerosis; and ovarian carcinoma. Is an ortholog of human RHOA (ras homolog family member A). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||
DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||||
DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||||
DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||||
DOID:4001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667,HGNC:669) | ||||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667,HGNC:668,HGNC:669) | ||||||
Molecular_info | Corresponding_CDS | Y51H4A.3a | |||||||
Corresponding_transcript | Y51H4A.3b | ||||||||
Y51H4A.3a.1 | |||||||||
Other_sequence | L36965 | ||||||||
JI257320.1 | |||||||||
SC00233 | |||||||||
EX559748.1 | |||||||||
ES568023.1 | |||||||||
Name_isotig06862 | |||||||||
BG467830.1 | |||||||||
EX562791.1 | |||||||||
XI03532 | |||||||||
XIC01137_1 | |||||||||
EW744313.1 | |||||||||
ES408820.1 | |||||||||
ACC25712_1 | |||||||||
DAC00438_1 | |||||||||
FE917869.1 | |||||||||
EX563220.1 | |||||||||
SC01360 | |||||||||
PSC03593_1 | |||||||||
EX916585.1 | |||||||||
JI218650.1 | |||||||||
HG10193 | |||||||||
EX565636.1 | |||||||||
SRC00631_1 | |||||||||
SR01626 | |||||||||
EW743883.1 | |||||||||
SS02573 | |||||||||
XI02266 | |||||||||
MH03164 | |||||||||
JI469707.1 | |||||||||
BU586435.1 | |||||||||
DW718391.1 | |||||||||
TSC04003_1 | |||||||||
EY466992.1 | |||||||||
MHC00247_1 | |||||||||
FG348258.1 | |||||||||
PTC02908_1 | |||||||||
BU586027.1 | |||||||||
FE918075.1 | |||||||||
EX560232.1 | |||||||||
TS04880 | |||||||||
ACC22570_1 | |||||||||
PT03610 | |||||||||
BXC05144_1 | |||||||||
EX534833.1 | |||||||||
ACC15314_1 | |||||||||
OF00782 | |||||||||
GR977561.1 | |||||||||
FC555498.1 | |||||||||
FG619688.1 | |||||||||
ALC00445_1 | |||||||||
DA05266 | |||||||||
EW741514.1 | |||||||||
EX566083.1 | |||||||||
RS08282 | |||||||||
EX561893.1 | |||||||||
GW407248.1 | |||||||||
HGC09124_1 | |||||||||
JI464442.1 | |||||||||
DA05517 | |||||||||
XIC01092_1 | |||||||||
GR978058.1 | |||||||||
EX541330.1 | |||||||||
EX558157.1 | |||||||||
DA06076 | |||||||||
ES743110.1 | |||||||||
GW409272.1 | |||||||||
CR10807 | |||||||||
Associated_feature (14) | |||||||||
Experimental_info | RNAi_result (53) | ||||||||
Expr_pattern (11) | |||||||||
Construct_product (11) | |||||||||
Antibody | WBAntibody00000091 | ||||||||
WBAntibody00001137 | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (119) | |||||||||
Interaction (279) | |||||||||
Map_info | Map | IV | Position | 15.09 | Error | 0.001168 | |||
Positive | Positive_clone | Y51H4A | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (126) | |||||||||
Remark | Sequence connection from [Spencer AG, Han M] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |