pph-5 encodes a protein phosphatase that is the sole C. elegans ortholog of protein phosphatase 5; during anaphase, PPH-5 negatively regulates the cortical granule exocytosis and cytokinesis activities of SEP-1/separase; in this capactiy, PPH-5 appears to function to regulate SEP-1 localization to vesicles at the appropriate times during cell division; pph-5 is expressed throughout development in both the soma and the germ line; in the germ line, a GFP::PPH-5 is cytoplasmic during interphase, becomes enriched at the spindle matrix during mitosis, and then disperses from the spindle during anaphase.
Enables Hsp90 protein binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of exocytosis and protein localization to organelle. Located in cytoplasm; mitotic spindle; and protein-containing complex. Expressed in several structures, including touch receptor neurons. Is an ortholog of human PPP5C (protein phosphatase 5 catalytic subunit).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.