WormBase Tree Display for Gene: WBGene00006870

WBGene00006870 SMap: S_parent: Sequence: F14F3
  Identity: Version: 2
    Name: CGC_name: vab-3 Person_evidence: WBPerson77
      Sequence_name: F14F3.1
      Molecular_name: F14F3.1a
        F14F3.1a.1
        CE24899
        F14F3.1b
        CE28216
        F14F3.1c
        CE28217
        F14F3.1a.2
        F14F3.1b.1
        F14F3.1c.1
      Other_name: lin-20
        mab-18 CGC_data_submission
        pax-6
        sax-4 Paper_evidence: WBPaper00003665
        CELE_F14F3.1 Accession_evidence: NDB BX284606
      Public_name: vab-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 08 Oct 2013 00:00:00 WBPerson2970 Name_change: Other_name: sax-4
    Status: Live
  Gene_info (12)
  Disease_info: Potential_model (14)
    Disease_relevance: The human ortholog, PAX6 (Paired box gene 6), is mutated in several developmental disorders that include disorders of eye development, like Aniridia, Coloboma, Gillespie syndrome, Keratitis, Peters anamaly and Optic nerve hypoplasia; PAX6 proteins are highly conserved, contain a paired domain (PD) and the homeodomain (HD), which are DNA binding domains and are involved in brain and eye development in many species as regulators of transcription; in C. elegans, the pax-6 gene encodes several isoforms, mutant studies of which, indicate that paired-domain (PD) containing isoforms are involved in epidermal morphogenesis, epidermal cell fates, and gonad cell migration; mutations in non-PD isoforms affect the fate of sensory structures in the mail tale; further, PAX-6 isoforms can have an additive, synergistic or antagonistic interaction depending on cellular context. Homo sapiens Paper_evidence: WBPaper00024640
          Accession_evidence: OMIM 604219
              120430
              120200
              136520
              206700
              148190
              165550
              60422
          Curator_confirmed: WBPerson324
          Date_last_updated: 02 May 2012 00:00:00
  Molecular_info: Corresponding_CDS: F14F3.1a
      F14F3.1b
      F14F3.1c
    Corresponding_CDS_history: F14F3.1:wp47
    Corresponding_transcript: F14F3.1a.1
      F14F3.1a.2
      F14F3.1b.1
      F14F3.1c.1
    Other_sequence (24)
    Associated_feature (38)
    Gene_product_binds: WBsf027927
      WBsf977965
    Transcription_factor: WBTranscriptionFactor000105
  Experimental_info: RNAi_result (19)
    Expr_pattern (21)
    Drives_construct (16)
    Construct_product: WBCnstr00000175
      WBCnstr00000176
      WBCnstr00018671
      WBCnstr00018672
      WBCnstr00018673
      WBCnstr00034118
    Antibody: WBAntibody00000202
      WBAntibody00000203
      WBAntibody00001432
    Microarray_results (38)
    Expression_cluster (178)
    Interaction (458)
    Anatomy_function: WBbtf0613
  Map_info: Map: X Position: 2.22417 Error: 0.001647
    Well_ordered
    Positive: Positive_clone: C33D3
        C56D7
        CB11
        F14F3 Inferred_automatically: From sequence, transcript, pseudogene data
        M4B
    Negative: Negative_clone: AF4
        C12H7
        C29G11
        C39B10
        K08A5
        ZC504
    Mapping_data: 2_point (12)
      Multi_point (26)
      Pos_neg_data (14)
    Landmark_gene
  Reference: WBPaper00000214
    WBPaper00000608
    WBPaper00000787
    WBPaper00000978
    WBPaper00001057
    WBPaper00001471
    WBPaper00001829
    WBPaper00002228
    WBPaper00002235
    WBPaper00002236
    WBPaper00002475
    WBPaper00002828
    WBPaper00002924
    WBPaper00002948
    WBPaper00003341
    WBPaper00003598
    WBPaper00003599
    WBPaper00003665
    WBPaper00003760
    WBPaper00003780
    WBPaper00003935
    WBPaper00003990
    WBPaper00004438
    WBPaper00004489
    WBPaper00004825
    WBPaper00004883
    WBPaper00005834
    WBPaper00006052
    WBPaper00006286
    WBPaper00006506
    WBPaper00010325
    WBPaper00010397
    WBPaper00010966
    WBPaper00010980
    WBPaper00010981
    WBPaper00011066
    WBPaper00011240
    WBPaper00012518
    WBPaper00013792
    WBPaper00014082
    WBPaper00014225
    WBPaper00014314
    WBPaper00014771
    WBPaper00014777
    WBPaper00014840
    WBPaper00014973
    WBPaper00015090
    WBPaper00015141
    WBPaper00015177
    WBPaper00015295
    WBPaper00015401
    WBPaper00015426
    WBPaper00015427
    WBPaper00015437
    WBPaper00015502
    WBPaper00016625
    WBPaper00017246
    WBPaper00017247
    WBPaper00017320
    WBPaper00018100
    WBPaper00018144
    WBPaper00018145
    WBPaper00018201
    WBPaper00018933
    WBPaper00019672
    WBPaper00019784
    WBPaper00020814
    WBPaper00021756
    WBPaper00021784
    WBPaper00021795
    WBPaper00021796
    WBPaper00021866
    WBPaper00022119
    WBPaper00022265
    WBPaper00022276
    WBPaper00022409
    WBPaper00022593
    WBPaper00022979
    WBPaper00023095
    WBPaper00023188
    WBPaper00024018
    WBPaper00024640
    WBPaper00025069
    WBPaper00025654
    WBPaper00025897
    WBPaper00026309
    WBPaper00026316
    WBPaper00026796
    WBPaper00027278
    WBPaper00027299
    WBPaper00027309
    WBPaper00027646
    WBPaper00029033
    WBPaper00030283
    WBPaper00030828
    WBPaper00031344
    WBPaper00031561
    WBPaper00031917
    WBPaper00032690
    WBPaper00033137
    WBPaper00034543
    WBPaper00034710
    WBPaper00034843
    WBPaper00036735
    WBPaper00036830
    WBPaper00037789
    WBPaper00038491
    WBPaper00038670
    WBPaper00039672
    WBPaper00039849
    WBPaper00041771
    WBPaper00042780
    WBPaper00048186
    WBPaper00052211
    WBPaper00053837
    WBPaper00054665
    WBPaper00055090
    WBPaper00056064
    WBPaper00056425
    WBPaper00057409
    WBPaper00058130
    WBPaper00058804
    WBPaper00060123
    WBPaper00061738
    WBPaper00062430
    WBPaper00064401
    WBPaper00064487
  Remark (2)
  Method: Gene