WormBase Tree Display for Gene: WBGene00001842
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WBGene00001842 | SMap | S_parent | Sequence | ZK287 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | her | ||||||
Reference_allele | WBVar00144068 | ||||||
WBVar00089681 | |||||||
Allele (115) | |||||||
Legacy_information | Class 1 (loss-of-function) : e1518 : XX animals wildtype XO animals transformed into fertile hermaphrodites. ES3 (XO). Similar phenotype in e1518/Df. NA > 12 (e1520 e1561ts etc.). | ||||||
Class 2 (gain-of-function) : n695sd ts : XO animals wildtype XX animals partly masculinized egglaying defective hermaphrodites; n695/+ XX animals slightly masculinized. ES2 (XX). NA1. Intragenic revertants have Class 1 phenotype. NA (ird) > 4. | |||||||
See also e1518, e1519, e1520, e2296, n695, n826, n827, y8, y10, y14 | |||||||
[C.elegansII] e1518 : XX animals WT, XO animals transformed into fertile hermaphrodites. ES3 (XO). Similar phenotype in e1518/Df. OA>20: e1520, e1561ts (XO fertile male 15C, fertile hermaphrodite25C), q428ts (very weak Her), etc. Also gain-of-function alleles: n695sd,ts(XO animals WT, XX animals partly masculinized Egl hermaphrodites; n695/+ XX animals slightly masculinized),y101 (stronger masculinization, still incomplete). Intragenic revertants are recessive Her-1 alleles:n695n826, y1hv101 (viable deletion), etc. ES2 (XX). NA1. Intragenic revertants have Class 1 phenotype. Cloned: 0.8 and 1.2 kb transcripts, XO specific;1.2 kb transcript necessary and sufficient, encodes175 aa predicted cysteine-rich novel protein with signal sequence. [Hodgkin 1980; Perry et al. 1993, 1994; NT; PA] | |||||||
Strain | WBStrain00026851 | ||||||
WBStrain00027405 | |||||||
WBStrain00035135 | |||||||
WBStrain00035105 | |||||||
WBStrain00003987 | |||||||
WBStrain00004354 | |||||||
WBStrain00004355 | |||||||
WBStrain00004652 | |||||||
WBStrain00040284 | |||||||
WBStrain00040305 | |||||||
WBStrain00040285 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00044186 | ||||||
00044187 | |||||||
00044188 | |||||||
00044189 | |||||||
00044190 | |||||||
00044191 | |||||||
Ortholog (26) | |||||||
Structured_description | Concise_description | her-1 generates two transcripts, the larger of which encodes a small,secreted, cysteine-rich protein (HER-1A) required for normal sexdetermination in wild-type XO male animals, while being dispensable forsex determination in XX hermaphrodites; transcription of her-1 in XXanimals is repressed by SDC-2; HER-1A protein has two all-helicaldomains, with fourteen conserved cysteine residues forming sevendisulfide bonds, at least eight of which residues are critical forfunction in vivo; HER-1A has no known homologs except in other nematodes(e.g., Brugia malayi), and does not structurally resemble otherwell-known secreted proteins; HER-1A inhibits the receptor TRA-2A invivo, and binds it in vitro; HER-1A functions nonautonomously andrequires a signal sequence for biological activity; the her-1(n695gf)mutation alters a site in the her-1 promoter bound by SDC-2, partiallytransforms XX animals into phenotypic males, and requires sup-26 andsup-27 to do so. | Paper_evidence | WBPaper00000498 | |||
WBPaper00001067 | |||||||
WBPaper00001416 | |||||||
WBPaper00001496 | |||||||
WBPaper00001692 | |||||||
WBPaper00002034 | |||||||
WBPaper00003644 | |||||||
WBPaper00005215 | |||||||
WBPaper00005578 | |||||||
WBPaper00024344 | |||||||
Person_evidence | WBPerson479 | ||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 13 Feb 2007 00:00:00 | ||||||
Automated_description | Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | ZK287.8a | |||||
ZK287.8b | |||||||
Corresponding_CDS_history | ZK287.8b:wp227 | ||||||
Corresponding_transcript | ZK287.8a.1 | ||||||
ZK287.8b.1 | |||||||
Other_sequence | FD515802.1 | ||||||
CSC02098_1 | |||||||
Associated_feature | WBsf019092 | ||||||
WBsf019093 | |||||||
WBsf647101 | |||||||
WBsf661583 | |||||||
WBsf1000974 | |||||||
WBsf1000975 | |||||||
WBsf1000976 | |||||||
WBsf1020212 | |||||||
WBsf1020213 | |||||||
Experimental_info | RNAi_result | WBRNAi00021950 | Inferred_automatically | RNAi_primary | |||
WBRNAi00059334 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00087454 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030278 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1391 | ||||||
Expr1019921 | |||||||
Expr1162763 | |||||||
Expr2012399 | |||||||
Expr2030635 | |||||||
Drives_construct | WBCnstr00000369 | ||||||
WBCnstr00000370 | |||||||
WBCnstr00036652 | |||||||
Construct_product | WBCnstr00036652 | ||||||
WBCnstr00040211 | |||||||
Microarray_results (27) | |||||||
Expression_cluster (121) | |||||||
Interaction (125) | |||||||
WBProcess | WBbiopr:00000056 | ||||||
Map_info | Map | V | Position | 2.07413 | Error | 0.004197 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf31 | |||||
ctDp11 | |||||||
Positive_clone | CT#4 | ||||||
ZK287 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 633 | |||||
634 | |||||||
Multi_point | 329 | ||||||
544 | |||||||
545 | |||||||
546 | |||||||
547 | |||||||
739 | |||||||
1786 | |||||||
3892 | |||||||
Pos_neg_data | 378 | ||||||
1736 | |||||||
1737 | |||||||
Reference (253) | |||||||
Picture | WBPicture0000013095 | ||||||
Method | Gene |