WormBase Tree Display for Gene: WBGene00000223

WBGene00000223 SMap: S_parent: Sequence: C07G2
  Identity: Version: 2
    Name: CGC_name: atf-7 Person_evidence: WBPerson531
      Sequence_name: C07G2.2
      Molecular_name (16)
      Other_name: CELE_C07G2.2 Accession_evidence: NDB BX284603
      Public_name: atf-7
    DB_info: Database: AceView gene 3F582
        WormQTL gene WBGene00000223
        WormFlux gene WBGene00000223
        NDB locus_tag CELE_C07G2.2
        Panther gene CAEEL|WormBase=WBGene00000223|UniProtKB=Q86MD3
          family PTHR19304
        NCBI gene 175587
        RefSeq protein NM_065513.5
            NM_065512.5
            NM_001384076.2
            NM_001393322.1
        SwissProt UniProtAcc Q86MD3
        UniProt_GCRP UniProtAcc Q86MD3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 10:40:20 WBPerson4025 Event: Split_into: WBGene00303035
      Split_into: WBGene00303035
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atf
    Allele (100)
    Strain: WBStrain00035313
      WBStrain00035314
      WBStrain00035315
      WBStrain00036658
      WBStrain00037729
      WBStrain00037749
      WBStrain00040810
      WBStrain00040811
      WBStrain00040812
      WBStrain00040813
    RNASeq_FPKM (74)
    GO_annotation (31)
    Contained_in_operon: CEOP3192
    Ortholog (36)
    Structured_description: Concise_description: atf-7 encodes a basic-region leucine zipper (bZIP) transcription factor orthologous to members of the ATF2/ATF7/CREB5 family of cyclic AMP-response element binding (CREB)/activating transcription factors (ATFs); ATF-7 plays a key role in the innate immune response by regulating the expression of immune genes downstream of PMK-1/p38 MAPK; ATF-7 is likely converted from a transcriptional repressor to a transcriptional activator in response to phosphorylation by activated PMK-1 with which it physically interacts and serves as a substrate in heterologous expression assays; an ATF-7::GFP reporter fusion is expressed in the intestine and localizes to the nucleus. Paper_evidence: WBPaper00036086
          Curator_confirmed: WBPerson1843
          Date_last_updated: 07 Apr 2010 00:00:00
      Automated_description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mitogen-activated protein kinase binding activity. Involved in several processes, including defense response to bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in nucleus. Part of chromatin. Expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; colorectal cancer; and schizophrenia. Is an ortholog of human ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:792)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:784)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:784)
      DOID:11870 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:784)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:784)
  Molecular_info: Corresponding_CDS: C07G2.2a
      C07G2.2b
      C07G2.2c
      C07G2.2d
    Corresponding_CDS_history: C07G2.2a:wp98
      C07G2.2e:wp264
    Corresponding_transcript: C07G2.2a.1
      C07G2.2b.1
      C07G2.2b.2
      C07G2.2c.1
      C07G2.2d.1
      C07G2.2d.2
      C07G2.2d.3
      C07G2.2d.4
    Other_sequence (34)
    Associated_feature (19)
    Transcription_factor: WBTranscriptionFactor000148
  Experimental_info: RNAi_result: WBRNAi00040021 Inferred_automatically: RNAi_primary
      WBRNAi00028646 Inferred_automatically: RNAi_primary
      WBRNAi00095299 Inferred_automatically: RNAi_primary
      WBRNAi00040020 Inferred_automatically: RNAi_primary
      WBRNAi00006802 Inferred_automatically: RNAi_primary
      WBRNAi00040022 Inferred_automatically: RNAi_primary
      WBRNAi00094624 Inferred_automatically: RNAi_primary
      WBRNAi00093236 Inferred_automatically: RNAi_primary
      WBRNAi00007139 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00001123
      WBCnstr00001124
      WBCnstr00001125
      WBCnstr00006677
      WBCnstr00012564
      WBCnstr00014310
      WBCnstr00014328
      WBCnstr00037649
    Construct_product: WBCnstr00006677
      WBCnstr00021921
      WBCnstr00022551
      WBCnstr00037649
    Regulate_expr_cluster: WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
    Microarray_results (47)
    Expression_cluster (105)
    Interaction (39)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: III Position: -3.15041 Error: 0.001925
    Positive: Positive_clone: C07G2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (43)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene