cka-2 encodes an isoform of choline kinase whose activity has beenverified in vitro; CKA-1 and CKA-2 comprise a related group ('A') ofcholine kinases; purified CKA-2 is dimeric, requires 1 mM Mg(2+) foroptimal activity, and has a strong preference for choline overethanolamine; CKA-2 has a pH optimum of 10 and a k(cat) of 74/s, close tothe maximum rate observed for yeast and rat enzymes.
Enables choline kinase activity. Involved in CDP-choline pathway. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including colon adenoma; megaconial type congenital muscular dystrophy; narcolepsy; and recurrent hypersomnia. Is an ortholog of human CHKA (choline kinase alpha).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.