WormBase Tree Display for Gene: WBGene00001966
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WBGene00001966 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C17C3 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | hlh-27 | Person_evidence | WBPerson346 | |||
Sequence_name | C17C3.10 | ||||||
Molecular_name | C17C3.10 | ||||||
C17C3.10.1 | |||||||
CE46787 | |||||||
Other_name | CELE_C17C3.10 | Accession_evidence | NDB | BX284602 | |||
Public_name | hlh-27 | ||||||
DB_info | Database | AceView | gene | 2F828 | |||
WormQTL | gene | WBGene00001966 | |||||
WormFlux | gene | WBGene00001966 | |||||
NDB | locus_tag | CELE_C17C3.10 | |||||
Panther | gene | CAEEL|WormBase=WBGene00001966|UniProtKB=Q18056 | |||||
family | PTHR10985 | ||||||
NCBI | gene | 182719 | |||||
RefSeq | protein | NM_062664.4 | |||||
TREEFAM | TREEFAM_ID | TF322171 | |||||
TrEMBL | UniProtAcc | Q18056 | |||||
UniProt_GCRP | UniProtAcc | Q18056 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | hlh | ||||||
Allele (17) | |||||||
Strain | WBStrain00051158 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00060095 | ||||||
00060096 | |||||||
00060097 | |||||||
00060098 | |||||||
00060099 | |||||||
00060100 | |||||||
00109819 | |||||||
Ortholog (22) | |||||||
Paralog | WBGene00001964 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Inparanoid_8 | |||||||
WormBase-Compara | |||||||
WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Inparanoid_8 | |||||||
WormBase-Compara | |||||||
WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Inparanoid_8 | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 | |||
WBPaper00025235 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 18 Apr 2008 00:00:00 | ||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including ABpla; ABplp; ABprp; MSaa; and MSpa. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C17C3.10 | |||||
Corresponding_CDS_history | C17C3.10:wp228 | ||||||
Corresponding_transcript | C17C3.10.1 | ||||||
Associated_feature | WBsf978830 | ||||||
WBsf981202 | |||||||
WBsf223060 | |||||||
Transcription_factor | WBTranscriptionFactor000074 | ||||||
Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary | |||
WBRNAi00010899 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084010 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00040773 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00024579 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00040785 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027179 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr3496 | ||||||
Expr8068 | |||||||
Expr1028370 | |||||||
Expr1144810 | |||||||
Expr2012502 | |||||||
Expr2030741 | |||||||
Drives_construct | WBCnstr00005213 | ||||||
WBCnstr00011428 | |||||||
WBCnstr00015158 | |||||||
WBCnstr00036554 | |||||||
Construct_product | WBCnstr00005213 | ||||||
WBCnstr00016893 | |||||||
WBCnstr00036554 | |||||||
Microarray_results (3) | |||||||
Expression_cluster (48) | |||||||
Interaction (182) | |||||||
Map_info | Map | II | Position | -1.18532 | Error | 0.00229 | |
Positive | Positive_clone | C17C3 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00025235 | ||||||
WBPaper00027287 | |||||||
WBPaper00027309 | |||||||
WBPaper00029033 | |||||||
WBPaper00034761 | |||||||
WBPaper00062117 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |