WormBase Tree Display for Gene: WBGene00001966
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WBGene00001966 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C17C3 | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | hlh | |||||
Allele (17) | ||||||
Strain | WBStrain00051158 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation | 00060095 | |||||
00060096 | ||||||
00060097 | ||||||
00060098 | ||||||
00060099 | ||||||
00060100 | ||||||
00109819 | ||||||
Ortholog (22) | ||||||
Paralog | WBGene00001964 | Caenorhabditis elegans | From_analysis | TreeFam | ||
Inparanoid_8 | ||||||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00001965 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | ||||||
WormBase-Compara | ||||||
WBGene00003008 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00001968 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | ||||||
WormBase-Compara | ||||||
WBGene00001967 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | ||||||
WormBase-Compara | ||||||
Structured_description | Concise_description | hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00006395 | ||
WBPaper00025235 | ||||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 18 Apr 2008 00:00:00 | |||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including ABpla; ABplp; ABprp; MSaa; and MSpa. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | C17C3.10 | ||||
Corresponding_CDS_history | C17C3.10:wp228 | |||||
Corresponding_transcript | C17C3.10.1 | |||||
Associated_feature | WBsf978830 | |||||
WBsf981202 | ||||||
WBsf223060 | ||||||
Transcription_factor | WBTranscriptionFactor000074 | |||||
Experimental_info | RNAi_result | WBRNAi00010905 | Inferred_automatically | RNAi_primary | ||
WBRNAi00010899 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00084010 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00040773 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00024579 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00040785 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00027179 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr3496 | |||||
Expr8068 | ||||||
Expr1028370 | ||||||
Expr1144810 | ||||||
Expr2012502 | ||||||
Expr2030741 | ||||||
Drives_construct | WBCnstr00005213 | |||||
WBCnstr00011428 | ||||||
WBCnstr00015158 | ||||||
WBCnstr00036554 | ||||||
Construct_product | WBCnstr00005213 | |||||
WBCnstr00016893 | ||||||
WBCnstr00036554 | ||||||
Microarray_results | SMD_C17C3.10 | |||||
SMD_C17C3.11 | ||||||
A_12_P151226 | ||||||
Expression_cluster (48) | ||||||
Interaction (182) | ||||||
Map_info (3) | ||||||
Reference | WBPaper00025235 | |||||
WBPaper00027287 | ||||||
WBPaper00027309 | ||||||
WBPaper00029033 | ||||||
WBPaper00034761 | ||||||
WBPaper00062117 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |