WormBase Tree Display for Gene: WBGene00003822
expand all nodes | collapse all nodes | view schema
WBGene00003822 | SMap | S_parent | Sequence | CHROMOSOME_II | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nsy | ||||||
Allele (121) | |||||||
Legacy_information | ky400 homozygotes lose neuronal asymmetry, express str-2::GFPin both AWC neurons. ky542, ky397 similar.All 3 probable nulls: stop codons in F59A6.1, encoding homolog of Human MAPKKK ASK1. | ||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (59) | |||||||
Ortholog (51) | |||||||
Paralog | WBGene00004161 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | nsy-1 encodes a MAP kinase kinase kinase (MAP3K) that is orthologous to the mammalian apoptosis signal-regulating kinase (ASK) family of protein kinases; nsy-1 activity is required for chemotaxis, egg laying, pathogen response, and response to anoxia; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; NSY-1 interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. | Paper_evidence | WBPaper00003760 | |||
WBPaper00004610 | |||||||
WBPaper00004669 | |||||||
WBPaper00005370 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 11 Jan 2011 00:00:00 | ||||||
Automated_description | Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:670 | Homo sapiens | Paper_evidence | WBPaper00038418 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 31 May 2019 00:00:00 | ||||||
Potential_model | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6857) | |||
DOID:8677 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6857) | ||||
Models_disease_asserted | WBDOannot00000693 | ||||||
Molecular_info | Corresponding_CDS | F59A6.1a | |||||
F59A6.1b | |||||||
Corresponding_CDS_history | F59A6.1c:wp264 | ||||||
Corresponding_transcript | F59A6.1a.1 | ||||||
F59A6.1b.1 | |||||||
Other_sequence (29) | |||||||
Associated_feature | WBsf657564 | ||||||
WBsf987777 | |||||||
WBsf987778 | |||||||
WBsf987779 | |||||||
WBsf987780 | |||||||
WBsf1012168 | |||||||
WBsf1012169 | |||||||
WBsf221219 | |||||||
Experimental_info (11) | |||||||
Map_info | Map | II | Position | -2.59263 | Error | 0.001611 | |
Positive (2) | |||||||
Negative | Outside_rearr | ccDf11 | |||||
Mapping_data | Pos_neg_data | 10652 | |||||
10653 | |||||||
10654 | |||||||
10655 | |||||||
Reference (158) | |||||||
Picture | WBPicture0000013079 | ||||||
WBPicture0000013081 | |||||||
WBPicture0000013093 | |||||||
Remark | Sequence connection (nsy-1 = F59A6.1) from Sagasti A and Bargmann C [030204 ck1] | ||||||
Method | Gene |