WormBase Tree Display for Gene: WBGene00005152
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WBGene00005152 | Identity (5) | ||||||
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Gene_info | Gene_class | srf | |||||
Reference_allele | WBVar00275419 | ||||||
Allele (49) | |||||||
Legacy_information | [C.elegansII] yj262 : increased binding of anti-cuticle antiserum, ectopic lectin WGA binding, no labelling with L1-specific mAb M38. Gross morphology WT.OA>20: yj133, yj422, ct104, ct117, dv1, dv2, dv37etc. All alleles recessive. [Hemmer et al. 1991; Link et al. 1992; AT; CL] | ||||||
Strain | WBStrain00022558 | ||||||
WBStrain00000251 | |||||||
WBStrain00004666 | |||||||
WBStrain00004729 | |||||||
WBStrain00004768 | |||||||
Structured_description | Concise_description | srf-2 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-2 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-2 mutants are resistant to infection by the nematode-specific pathogen, Microbacterium nematophilum, and do not show the tail-swelling response to infection; srf-2 mutants also show an altered response to nematophagous fungi, in the form of increased susceptibility. | Paper_evidence | WBPaper00001576 | |||
WBPaper00001002 | |||||||
WBPaper00001706 | |||||||
WBPaper00001280 | |||||||
WBPaper00004539 | |||||||
WBPaper00003623 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 Oct 2011 00:00:00 | ||||||
Automated_description | Used to study bacterial infectious disease. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00029153 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 10 May 2023 00:00:00 | ||||||
Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||
WBPaper00029153 | |||||||
WBPaper00026735 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Mar 2013 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000014 | ||||||
Experimental_info (3) | |||||||
Map_info | Map | I | Position | 5.23624 | Error | 0.183128 | |
Mapping_data | 2_point | 4748 | |||||
4749 | |||||||
Multi_point | 1691 | ||||||
1692 | |||||||
3010 | |||||||
3011 | |||||||
3197 | |||||||
3198 | |||||||
Pos_neg_data | 8076 | ||||||
8088 | |||||||
8096 | |||||||
Reference (37) | |||||||
Method | Gene |