rsa-1 encodes a protein phosphatase 2A (PP2A) regulatory subunit of the B'' class; RSA-1 is required for localization of C. elegans PP2A to centrosomes and for mitotic spindle assembly; RSA-1 physically interacts with the LET-92 PP2A catalytic subunit and the PAA-1 PP2A structural subunit; centrosomal levels of PAA-1 are decreased in rsa-1 mutant animals; RSA-1 localizes to centrosomes.
Enables protein phosphatase 2A binding activity. Involved in embryo development; mitotic spindle assembly; and protein localization to organelle. Located in centrosome. Human ortholog(s) of this gene implicated in spermatogenic failure 36. Is an ortholog of human PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.