WormBase Tree Display for Gene: WBGene00008890

WBGene00008890 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: ser-5 Person_evidence: WBPerson32
            WBPerson3043
            WBPerson7103
      Sequence_name: F16D3.7
      Molecular_name: F16D3.7
        F16D3.7.1
        CE42717
      Other_name: CELE_F16D3.7 Accession_evidence: NDB BX284601
      Public_name: ser-5
    DB_info: Database: AceView gene 1I963
        WormQTL gene WBGene00008890
        WormFlux gene WBGene00008890
        NDB locus_tag CELE_F16D3.7
        Panther gene CAEEL|WormBase=WBGene00008890|UniProtKB=G5EBX8
          family PTHR24248
        NCBI gene 184572
        RefSeq protein NM_059872.3
        TrEMBL UniProtAcc G5EBX8
        UniProt_GCRP UniProtAcc G5EBX8
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 29 Oct 2007 11:47:39 WBPerson2970 Name_change: CGC_name: ser-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ser
    Allele (23)
    Strain: WBStrain00032956
      WBStrain00040307
      WBStrain00055583
      WBStrain00055584
      WBStrain00055581
      WBStrain00055063
      WBStrain00055576
      WBStrain00055575
      WBStrain00055580
      WBStrain00055571
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (32)
    Paralog: WBGene00004777 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00004780 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00006411 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00020506 Caenorhabditis elegans From_analysis: Panther
      WBGene00044004 Caenorhabditis elegans From_analysis: Panther
      WBGene00017157 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: ser-5 encodes a biogenic amine receptor that is most closely related to mammalian serotonin/5-HT-6 receptors; SER-5 functions in the ASH chemosensory neurons to coordinate sensory input and locomotory behavior and in muscles to regulate serotonin's effects on egg laying; heterologously expressed ser-5 has no effect on adenylate cyclase signaling; ser-5 reporter fusions are expressed in vulval and bodywall muscles and head neurons, including ASH and AWB. Paper_evidence: WBPaper00006525
            WBPaper00024527
            WBPaper00028762
            WBPaper00032345
            WBPaper00032881
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 07 Oct 2009 00:00:00
      Automated_description: Predicted to enable alpha1-adrenergic receptor activity. Involved in several processes, including pharyngeal pumping; positive regulation of egg-laying behavior; and serotonin receptor signaling pathway. Predicted to be located in membrane. Expressed in body wall musculature; egg-laying apparatus; and lateral ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Is an ortholog of human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:277)
      DOID:9976 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:277)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:277)
  Molecular_info: Corresponding_CDS: F16D3.7
    Corresponding_CDS_history: F16D3.7:wp192
    Corresponding_transcript: F16D3.7.1
    Other_sequence: CJC13360_1
      ES410466.1
      JI180041.1
      HBC15864_1
      ACC04223_1
    Associated_feature: WBsf656629
  Experimental_info: RNAi_result: WBRNAi00003401 Inferred_automatically: RNAi_primary
      WBRNAi00069707 Inferred_automatically: RNAi_primary
      WBRNAi00069723 Inferred_automatically: RNAi_primary
      WBRNAi00069731 Inferred_automatically: RNAi_primary
      WBRNAi00044804 Inferred_automatically: RNAi_primary
      WBRNAi00078847 Inferred_automatically: RNAi_primary
      WBRNAi00069699 Inferred_automatically: RNAi_primary
      WBRNAi00078846 Inferred_automatically: RNAi_primary
      WBRNAi00069715 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4337
      Expr5777
      Expr12135
      Expr12172
      Expr12174
      Expr1025650
      Expr1033875
      Expr1148769
      Expr2015750
      Expr2033983
    Drives_construct: WBCnstr00002087
      WBCnstr00006343
      WBCnstr00006359
      WBCnstr00011930
      WBCnstr00014552
      WBCnstr00020382
    Construct_product: WBCnstr00006343
      WBCnstr00006359
      WBCnstr00007233
      WBCnstr00014552
      WBCnstr00020382
    Microarray_results (19)
    Expression_cluster (96)
    Interaction: WBInteraction000277018
      WBInteraction000364409
      WBInteraction000396369
      WBInteraction000443577
      WBInteraction000517572
      WBInteraction000575525
  Map_info: Map: I Position: 2.77233 Error: 0.00378
    Positive: Positive_clone: F16D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (33)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene