WormBase Tree Display for Gene: WBGene00018788
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| WBGene00018788 | SMap | S_parent | Sequence | F54A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | shc-1 | Paper_evidence | WBPaper00004558 | |||||
| Person_evidence | WBPerson842 | ||||||||
| WBPerson50 | |||||||||
| Sequence_name | F54A5.3 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | CELE_F54A5.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | shc-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Oct 2006 16:44:09 | WBPerson2970 | Name_change | CGC_name | shc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | shc | ||||||||
| Allele (156) | |||||||||
| Strain | WBStrain00028776 | ||||||||
| WBStrain00001443 | |||||||||
| WBStrain00002891 | |||||||||
| WBStrain00054667 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | shc-1 encodes four proteins by multiple splicing, three of which are rather small (52-81 residues); however, one isoform (F54A5.3A, 316 residues) is a ortholog of vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like its orthologs, F54A5.3A has a PTB and an SH2 domain in N- to C-terminal order; shc-1 interacts with both the JNK and insulin signaling pathways to regulate stress response and adult life span; SHC-1::GFP is widely expressed during postembryonic development and localizes to both the cytoplasm and the nucleus. | Paper_evidence | WBPaper00004558 | |||||
| WBPaper00004651 | |||||||||
| WBPaper00032241 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Aug 2009 00:00:00 | ||||||||
| Automated_description | Enables insulin-like growth factor receptor binding activity; mitogen-activated protein kinase kinase binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of axon regeneration; response to endoplasmic reticulum stress; and response to metal ion. Located in cytoplasm and nucleus. Expressed in gonad; head; neurons; and tail. Human ortholog(s) of this gene implicated in fatty liver disease. Is an ortholog of human SHC4 (SHC adaptor protein 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9452 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10840) | ||||
| Molecular_info | Corresponding_CDS | F54A5.3a | |||||||
| F54A5.3b | |||||||||
| Corresponding_CDS_history | F54A5.3b:wp247 | ||||||||
| F54A5.3c:wp247 | |||||||||
| F54A5.3d:wp247 | |||||||||
| Corresponding_transcript | F54A5.3c | ||||||||
| F54A5.3d | |||||||||
| F54A5.3e | |||||||||
| F54A5.3f | |||||||||
| F54A5.3g | |||||||||
| F54A5.3a.1 | |||||||||
| F54A5.3b.1 | |||||||||
| F54A5.3b.2 | |||||||||
| F54A5.3b.3 | |||||||||
| Other_sequence | CR07333 | ||||||||
| CBC16603_1 | |||||||||
| CRC11104_1 | |||||||||
| Associated_feature | WBsf648924 | ||||||||
| WBsf982630 | |||||||||
| WBsf982631 | |||||||||
| WBsf982632 | |||||||||
| WBsf982633 | |||||||||
| WBsf1009169 | |||||||||
| WBsf1009170 | |||||||||
| WBsf1009171 | |||||||||
| WBsf1009172 | |||||||||
| WBsf218946 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00109620 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00109232 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048215 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032732 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007492 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032731 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094878 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109523 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109426 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109329 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00002323 | ||||||||
| WBCnstr00002324 | |||||||||
| WBCnstr00003044 | |||||||||
| WBCnstr00004306 | |||||||||
| WBCnstr00004520 | |||||||||
| WBCnstr00013271 | |||||||||
| WBCnstr00013295 | |||||||||
| WBCnstr00026277 | |||||||||
| Construct_product | WBCnstr00013295 | ||||||||
| WBCnstr00026277 | |||||||||
| Microarray_results (56) | |||||||||
| Expression_cluster (118) | |||||||||
| Interaction (103) | |||||||||
| WBProcess | WBbiopr:00000052 | ||||||||
| Map_info | Map | I | Position | -17.4191 | Error | 0.002963 | |||
| Positive | Positive_clone | F54A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
