WormBase Tree Display for Gene: WBGene00019830
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| WBGene00019830 | SMap | S_parent | Sequence | R02E12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | hrg-1 | Person_evidence | WBPerson1802 | |||||
| Sequence_name | R02E12.6 | ||||||||
| Molecular_name | R02E12.6 | ||||||||
| R02E12.6.1 | |||||||||
| CE30099 | |||||||||
| R02E12.6.2 | |||||||||
| R02E12.6.3 | |||||||||
| Other_name | CELE_R02E12.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | hrg-1 | ||||||||
| DB_info | Database | AceView | gene | XE628 | |||||
| WormQTL | gene | WBGene00019830 | |||||||
| WormFlux | gene | WBGene00019830 | |||||||
| NDB | locus_tag | CELE_R02E12.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00019830|UniProtKB=Q21642 | |||||||
| family | PTHR31525 | ||||||||
| NCBI | gene | 180684 | |||||||
| RefSeq | protein | NM_001383555.2 | |||||||
| SwissProt | UniProtAcc | Q21642 | |||||||
| TREEFAM | TREEFAM_ID | TF317220 | |||||||
| UniProt_GCRP | UniProtAcc | Q21642 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Apr 2008 13:26:44 | WBPerson2970 | Name_change | CGC_name | hrg-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hrg | ||||||||
| Allele (134) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00009493 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009494 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009495 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hrg-1 encodes a transmembrane protein that is orthologous to vertebrate heme transporters;in C. elegans, hrg-1 functions to mediate heme homeostasis, likely by regulatingintracellular heme availability from endosomal or lysosomal-like compartments; HRG-1 exhibits pH-dependent heme binding in vitro and when expressed in Xenopus oocytes, can stimulate heme-dependent currents; an hrg-1::gfp promoter fusion is expressed in the larval and adult intestine in response to heme deficiency; when expressed in HEK293 cells, HRG-1 localizes primarily to endosomes and lysosome-related organelles; HRG-1 function is likely conserved across species, as hrg-1 expression is able to rescue developmental defects seen in zebrafish hrg-1 mutants. | Paper_evidence | WBPaper00031703 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Aug 2009 00:00:00 | ||||||||
| Automated_description | Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in endosome membrane and lysosomal membrane. Is an ortholog of human SLC48A1 (solute carrier family 48 member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R02E12.6 | |||||||
| Corresponding_transcript | R02E12.6.1 | ||||||||
| R02E12.6.2 | |||||||||
| R02E12.6.3 | |||||||||
| Other_sequence | MIC00161_1 | ||||||||
| CBC16910_1 | |||||||||
| NB06886 | |||||||||
| MHC09841_1 | |||||||||
| MI03587 | |||||||||
| MI03607 | |||||||||
| MH08765 | |||||||||
| NBC02906_1 | |||||||||
| MI00310 | |||||||||
| NB07214 | |||||||||
| Associated_feature | WBsf653879 | ||||||||
| WBsf653880 | |||||||||
| WBsf670388 | |||||||||
| WBsf670389 | |||||||||
| WBsf670390 | |||||||||
| WBsf1004804 | |||||||||
| WBsf1004805 | |||||||||
| WBsf1004806 | |||||||||
| WBsf1022715 | |||||||||
| WBsf237237 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00051141 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00034536 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8081 | ||||||||
| Expr9141 | |||||||||
| Expr9859 | |||||||||
| Expr1019607 | |||||||||
| Expr1038595 | |||||||||
| Expr1154850 | |||||||||
| Expr2012593 | |||||||||
| Expr2030829 | |||||||||
| Drives_construct | WBCnstr00004989 | ||||||||
| WBCnstr00007555 | |||||||||
| WBCnstr00007556 | |||||||||
| WBCnstr00013098 | |||||||||
| WBCnstr00014369 | |||||||||
| WBCnstr00025564 | |||||||||
| Construct_product | WBCnstr00014369 | ||||||||
| WBCnstr00025564 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (255) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | X | Position | -8.74454 | Error | 0.052544 | |||
| Positive | Positive_clone | R02E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
