WormBase Tree Display for Gene: WBGene00019983
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| WBGene00019983 | SMap | S_parent | Sequence | R09E12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sti-1 | Paper_evidence | WBPaper00033208 | |||||
| Person_evidence | WBPerson476 | ||||||||
| Sequence_name | R09E12.3 | ||||||||
| Molecular_name | R09E12.3 | ||||||||
| R09E12.3.1 | |||||||||
| CE12646 | |||||||||
| Other_name | CELE_R09E12.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | sti-1 | ||||||||
| DB_info | Database | AceView | gene | 5B253 | |||||
| WormQTL | gene | WBGene00019983 | |||||||
| WormFlux | gene | WBGene00019983 | |||||||
| NDB | locus_tag | CELE_R09E12.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00019983|UniProtKB=O16259 | |||||||
| family | PTHR22904 | ||||||||
| NCBI | gene | 178587 | |||||||
| RefSeq | protein | NM_001380593.3 | |||||||
| SwissProt | UniProtAcc | O16259 | |||||||
| TREEFAM | TREEFAM_ID | TF317700 | |||||||
| UniProt_GCRP | UniProtAcc | O16259 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 24 Jun 2009 10:25:59 | WBPerson9133 | Name_change | CGC_name | sti-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sti | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00001706 | ||||||||
| WBStrain00037408 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000500 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00006781 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015916 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016375 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019893 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | sti-1 encodes the C. elegans ortholog of the Sti1/Hop family of heat shock cochaperones; sti-1 plays a role in stress response, as sti-1 mutant animals have a shortened lifespan, decreased fertility at 20C, 25C, and 30C, and decreased thermotolerance; genetic interaction studies suggest that sti-1 may function together with daf-16 in regulating thermotolerance; STI-1 physically interacts with a number of proteins including HSP-1/Hsp70 and DAF-21/Hsp90, as well as proteins involved in translation and localized to the endoplasmic reticulum; a STI-1::GFP reporter is widely expressed in embryos as well as larvae and adults, with expression found in the pharynx, intestine, neurons, vulva, body wall muscles and male sensory rays; STI-1 appears to be a cytoplasmic protein. | Paper_evidence | WBPaper00033208 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables ATPase inhibitor activity; Hsp70 protein binding activity; and Hsp90 protein binding activity. Involved in determination of adult lifespan; reproduction; and response to heat. Located in cytoplasm. Expressed in several structures, including gonad; male-specific anatomical entity; pharyngeal muscle cell; touch receptor neurons; and vulva. Is an ortholog of human STIP1 (stress induced phosphoprotein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R09E12.3 | |||||||
| Corresponding_transcript | R09E12.3.1 | ||||||||
| Other_sequence (119) | |||||||||
| Associated_feature | WBsf646649 | ||||||||
| WBsf981885 | |||||||||
| WBsf999212 | |||||||||
| WBsf231366 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002530 | ||||||||
| WBCnstr00013422 | |||||||||
| WBCnstr00013657 | |||||||||
| WBCnstr00025448 | |||||||||
| WBCnstr00038165 | |||||||||
| WBCnstr00038166 | |||||||||
| WBCnstr00038167 | |||||||||
| WBCnstr00042002 | |||||||||
| Construct_product | WBCnstr00013657 | ||||||||
| WBCnstr00025448 | |||||||||
| Regulate_expr_cluster | WBPaper00033208:STI-1_interacting | ||||||||
| Antibody | WBAntibody00001936 | ||||||||
| WBAntibody00001948 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (116) | |||||||||
| Map_info | Map | V | Position | -19.953 | |||||
| Positive | Positive_clone | R09E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-19.9512) | |||||||||
| Method | Gene |
