WormBase Tree Display for Gene: WBGene00020316
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WBGene00020316 | SMap | S_parent | Sequence | T07E3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | brc-2 | Person_evidence | WBPerson1551 | |||||
Sequence_name | T07E3.5 | ||||||||
Molecular_name | T07E3.5 | ||||||||
T07E3.5.1 | |||||||||
CE32718 | |||||||||
Other_name | 3H990 | Accession_evidence | EMBL | AY523518 | |||||
CELE_T07E3.5 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | brc-2 | ||||||||
DB_info | Database | AceView | gene | 3H990 | |||||
WormQTL | gene | WBGene00020316 | |||||||
WormFlux | gene | WBGene00020316 | |||||||
NDB | locus_tag | CELE_T07E3.5 | |||||||
NCBI | gene | 175962 | |||||||
RefSeq | protein | NM_066101.8 | |||||||
SwissProt | UniProtAcc | G5EG86 | |||||||
TREEFAM | TREEFAM_ID | TF343088 | |||||||
UniProt_GCRP | UniProtAcc | G5EG86 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 04 Nov 2004 16:11:20 | WBPerson2970 | Name_change | CGC_name | brc-2 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | brc | ||||||||
Allele (43) | |||||||||
Strain | WBStrain00036382 | ||||||||
WBStrain00006441 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Ortholog (24) | |||||||||
Structured_description | Concise_description | brc-2 encodes a BRC domain-containing protein that is homologous to human BRCA2 which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185); in C. elegans, BRC-2 activity is essential for RAD-51-mediated repair of meiotic and radiation-induced double-strand breaks (DSBs); BRC-2 physically interacts with RAD-51 and single-stranded DNA and is required for proper localization of RAD-51 to sites of DNA damage and stabilization of RAD-51-DNA filaments; BRC-2 can also promote RAD-51-independent DSB repair via single-strand annealing (SSA) when the homologous recombination (HR) and nonhomologous end joining pathways (NHEJ) are compromised; in nonirradiated animals, BRC-2 is seen at diffuse, low levels in germline nuclei, but upon radiation treatment BRC-2 localizes to discrete foci that coincide with presumptive sites of DNA damage. | Paper_evidence | WBPaper00025138 | |||||
WBPaper00026962 | |||||||||
WBPaper00027753 | |||||||||
WBPaper00029356 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 08 May 2007 00:00:00 | ||||||||
Automated_description | Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T07E3.5 | |||||||
Corresponding_CDS_history | T07E3.5:wp88 | ||||||||
Corresponding_transcript | T07E3.5.1 | ||||||||
Other_sequence | CJC14464_1 | ||||||||
Associated_feature | WBsf667022 | ||||||||
WBsf226879 | |||||||||
Experimental_info | RNAi_result | WBRNAi00052766 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005928 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00052765 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00008015 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00018374 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00035309 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr3478 | ||||||||
Expr1017015 | |||||||||
Expr1038851 | |||||||||
Expr1156374 | |||||||||
Expr2009649 | |||||||||
Expr2027888 | |||||||||
Drives_construct | WBCnstr00000420 | ||||||||
WBCnstr00025227 | |||||||||
Construct_product | WBCnstr00000420 | ||||||||
WBCnstr00025227 | |||||||||
Antibody | WBAntibody00000837 | ||||||||
WBAntibody00000838 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (102) | |||||||||
Interaction (38) | |||||||||
Map_info | Map | III | Position | -0.907107 | Error | 0.001414 | |||
Positive | Positive_clone | T07E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4172 | |||||||
Pseudo_map_position | |||||||||
Reference (27) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |