WormBase Tree Display for Interaction: WBInteraction000501184

WBInteraction000501184 Interaction_type: Genetic: Synthetic
    GI_module_one: A_phenotypic
    GI_module_three: Diverging
  Interactor: Interactor_overlapping_gene: WBGene00003558 Interactor_type: Effector
      WBGene00006809 Interactor_type: Affected
      WBGene00046897 Interactor_type: Affected
      WBGene00047278 Interactor_type: Affected
      WBGene00047448 Interactor_type: Affected
      WBGene00049242 Interactor_type: Affected
      WBGene00165476 Interactor_type: Affected
      WBGene00171539 Interactor_type: Affected
      WBGene00174308 Interactor_type: Affected
    Variation_interactor: WBVar00145462 Interactor_type: Effector
      WBVar00145465 Interactor_type: Affected
  Interaction_summary: While either single deletion mutants display normal locomotion, nca-1(gk9);nca-2(gk5) double mutants are fainters that fail to sustain sinusoidal locomotion and succumb to long periods of halting.
    In the presence of both high and low concentrations of extracellular Ca2+, nca(lf) mutants displayed a significant decrease in the frequency of spontaneous release (miniature postsynaptic current, mPSC).
    The double mutants also displayed significantly reduced evoked responses.
  Throughput: Low_throughput
  Interaction_phenotype: WBPhenotype:0001592
    WBPhenotype:0001319
    WBPhenotype:0001316
  Paper: WBPaper00031592