WormBase Tree Display for Interaction: WBInteraction000517502
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| WBInteraction000517502 | Interaction_type | Genetic | Synthetic | ||
|---|---|---|---|---|---|
| GI_module_one | A_phenotypic | ||||
| GI_module_three | Diverging | ||||
| Interactor | Interactor_overlapping_gene (14) | ||||
| Variation_interactor | WBVar00090802 | Interactor_type | Effector | ||
| WBVar00323164 | Interactor_type | Affected | |||
| WBVar00288072 | Interactor_type | Affected | |||
| Interaction_summary | Deletion of all members of the mir-51 family is lethal. Most of these animals die during embryogenesis or shortly after hatching. The lethality of the mir-51 family mutant can be rescued using transgenes carrying genomic constructs for any mir-51 family miRNA. Animals are 77.6% Pun. | ||||
| While the arcade cell extensions contribute to mouth formation in mir-51 family mutant embryos, their cell bodies are often incorrectly positioned: the arcade cell bodies are not associated with the pharyngeal basement membrane. The anterior depression is large, and in some cases the arcade cell bodies have moved anteriorly. | |||||
| Both WT and 3' MUT CDH-3 transgenes are expressed in mir-51 family mutant embryos. GFP expression from the bath-15::gfp::cdh-3 transgene is upregulated in mir-51 family mutants as compared to rescued animals. | |||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0000062 | ||||
| WBPhenotype:0001748 | |||||
| WBPhenotype:0001118 | |||||
| WBPhenotype:0000594 | |||||
| WBPhenotype:0001236 | |||||
| Paper | WBPaper00036127 |
