WormBase Tree Display for Interaction: WBInteraction000525382
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| WBInteraction000525382 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00004804 | Interactor_type | Effector | |
| WBGene00008419 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00275492 | Interactor_type | Effector | ||
| WBVar00250781 | Interactor_type | Affected | |||
| Interaction_summary | wdr-23(tm1817) worms that develop to the L4/young adult stage are highly resistant to the electrophile and reactive oxygen species generator juglone and live 22.7% (median lifespan) longer than wildtype N2 worms. Resistance to juglone was suppressed by skn-1(RNAi) and by an allele of skn-1(zu135) that introduces a premature stop codon before the DNA binding domain. The extended lifespan of wdr-23(tm1817) worms was also suppressed by skn-1(RNAi) and skn-1(zu135). | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0000061 | ||||
| WBPhenotype:0000154 | |||||
| WBPhenotype:0000031 | |||||
| Paper | WBPaper00046904 |
