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WormBase Tree Display for Variation: WBVar00089296

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Name Class

WBVar00089296NamePublic_namen170
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004848
WBStrain00026710
LaboratoryMT
StatusLive
AffectsGeneWBGene00001194
InteractorWBInteraction000051551
WBInteraction000500871
WBInteraction000500881
WBInteraction000500882
WBInteraction000524338
WBInteraction000525340
WBInteraction000549476
GeneticsMapping_dataIn_2_point735
In_multi_point631
1718
1719
2310
2311
In_pos_neg_data6857
6858
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
PenetranceHighPaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Range8080Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0000007Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
PenetranceIncompletePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0000062Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Remarkegl-27(n170) animals exhibited a 46% penetrant embryonic or L1 larval arrest (Table 1)Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
PenetranceIncomplete46% penetrantPaper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000093Paper_evidenceWBPaper00003450
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPerson2987
Remarkmales Lin, very abnormalPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
When Q/V5 did not divide in the embryo (inferred by the absence of Q at hatching), Q/V5 divided abnormally after hatching. In two cases for egl-27(n170), Q/V5 generated a cell lineage pattern similar to V5, as if Q/V5 were transformed to a V5-like cell. In two cases for egl-27(n170), the Q/V5 division pattern was not similar to that of either Q or V5 alone but retained characteristics of each (data not shown), as if Q/V5 were transformed to a hybrid fate between Q and V5.Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006017PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0006282PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Life_stageWBls:0000056PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBls:0000024PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000350Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkhermaphroditic tail spike. ES2 (adult).Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000417Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
RemarkThe Q/V5L cell failed to divide in 4 out of 6 egl-27(n170) embryos. The Q/V5R cell failed to divide in 3 out of 6 egl-27(n170) embryos.Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006017PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0006282PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000424Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Remarkegl-27(n170) animals exhibited varying abnormalities in MAB-5 expression in QL daughter cells, compared to wild type animals, as determined by antibody staining (Figure 3A)Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007274PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0007276PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentWhole-mount larvae, 3-6 hours post-hatching, were stained with polyclonal anti-MAB-5 antisera and the DNA stain DAPIPaper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000443Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkshort spiculesPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000469Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Remarkegl-27(n170) animals exhibited disrupted QL descendant migration at varying degrees of penetrance and severity (Figure 2A, 3B). In 9 out of 26 animals, the QL.ap (PQR) cell migrated towards the posterior but did not fully migrate to the posterior as in wild type. In 8 out of 26 animals, QL.paa (PVM) and QL.pap (SDQL) migrated aberrantly towards the anterior. In 5 out of 26 animals the QL.ap (PQR) cell aberrantly migrated far into the anterior of the animal.Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004096PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0004993PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000470Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
RemarkHSNs fail to arrive at their final destination (between P5/6 and V4)Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0000505Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkreduced raysPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000506Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkswollen bursaPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000594Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMigPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000631Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkvariable drug responsePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000695Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkpossibly abnormal vulvaPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000816Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
RemarkApproximately 50% of egl-27(n170) animals exhibited missing QL and/or QR neuroblasts at hatching (Table 1)Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
PenetranceIncomplete50% penetrantPaper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004056PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0004054PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000828Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
Remarkegl-27(n170) mutants exhibited an abnormal pattern of T cell lineages, with all descendants of T adopting a hypodermal or hypodermal-like fate, unlike wild type (Figure 1).Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006994PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0006996PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0006995PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBbt:0006997PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
WBPhenotype:0000862Paper_evidenceWBPaper00000635
Person_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPerson712
Remarkvariable bloating, moderate to severe; difficult to score (ES2) in adultPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceIncompletevariablePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001068Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
PenetranceIncompletevariablePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatment5 mg/ml serotoninPaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001336Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatmentAs described in Hodgkin, Horvitz, and Brenner (1979), six L4 males and six L4 dpy-11 hermaphrodites incubated for 24 hours, males removed, and hermaphrodites transferred to fresh dishes each day. Cross-progeny are counted.Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001340Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
PenetranceIncompletevariablePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatment0.75 mg/ml imipraminePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0002211Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
RemarkThe egl-27(n170) mutation results in a completely penetrant phasmid dye filling defect, indicative of abnormal T cell polarity (Table 1).Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
PenetranceCompletePaper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005425PATO:0000460Paper_evidenceWBPaper00003450
Curator_confirmedWBPerson2987
ReferenceWBPaper00022356
WBPaper00012673
WBPaper00000635
WBPaper00001105
WBPaper00003450
WBPaper00011766
MethodAllele