WormBase Tree Display for Variation: WBVar00089296
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WBVar00089296 | Name | Public_name | n170 | ||||||
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Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00004848 | ||||||||
WBStrain00026710 | |||||||||
Laboratory | MT | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001194 | |||||||
Interactor | WBInteraction000051551 | ||||||||
WBInteraction000500871 | |||||||||
WBInteraction000500881 | |||||||||
WBInteraction000500882 | |||||||||
WBInteraction000524338 | |||||||||
WBInteraction000525340 | |||||||||
WBInteraction000549476 | |||||||||
Genetics | Mapping_data | In_2_point | 735 | ||||||
In_multi_point | 631 | ||||||||
1718 | |||||||||
1719 | |||||||||
2310 | |||||||||
2311 | |||||||||
In_pos_neg_data | 6857 | ||||||||
6858 | |||||||||
Description | Phenotype | WBPhenotype:0000006 | Paper_evidence | WBPaper00001105 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Penetrance | High | Paper_evidence | WBPaper00001105 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Range | 80 | 80 | Paper_evidence | WBPaper00001105 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00001105 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000007 | Paper_evidence | WBPaper00000635 | |||||||
Curator_confirmed | WBPerson48 | ||||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00000635 | ||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0000062 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | egl-27(n170) animals exhibited a 46% penetrant embryonic or L1 larval arrest (Table 1) | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Incomplete | 46% penetrant | Paper_evidence | WBPaper00003450 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000093 | Paper_evidence | WBPaper00003450 | |||||||
Person_evidence | WBPerson261 | ||||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPerson2987 | |||||||||
Remark | males Lin, very abnormal | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
When Q/V5 did not divide in the embryo (inferred by the absence of Q at hatching), Q/V5 divided abnormally after hatching. In two cases for egl-27(n170), Q/V5 generated a cell lineage pattern similar to V5, as if Q/V5 were transformed to a V5-like cell. In two cases for egl-27(n170), the Q/V5 division pattern was not similar to that of either Q or V5 alone but retained characteristics of each (data not shown), as if Q/V5 were transformed to a hybrid fate between Q and V5. | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006017 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006282 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Life_stage | WBls:0000056 | PATO:0000460 | Person_evidence | WBPerson261 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000350 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | hermaphroditic tail spike. ES2 (adult). | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000417 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | The Q/V5L cell failed to divide in 4 out of 6 egl-27(n170) embryos. The Q/V5R cell failed to divide in 3 out of 6 egl-27(n170) embryos. | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006017 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006282 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000424 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | egl-27(n170) animals exhibited varying abnormalities in MAB-5 expression in QL daughter cells, compared to wild type animals, as determined by antibody staining (Figure 3A) | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0007274 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0007276 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00003450 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Treatment | Whole-mount larvae, 3-6 hours post-hatching, were stained with polyclonal anti-MAB-5 antisera and the DNA stain DAPI | Paper_evidence | WBPaper00003450 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000443 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | short spicules | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Person_evidence | WBPerson261 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000469 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | egl-27(n170) animals exhibited disrupted QL descendant migration at varying degrees of penetrance and severity (Figure 2A, 3B). In 9 out of 26 animals, the QL.ap (PQR) cell migrated towards the posterior but did not fully migrate to the posterior as in wild type. In 8 out of 26 animals, QL.paa (PVM) and QL.pap (SDQL) migrated aberrantly towards the anterior. In 5 out of 26 animals the QL.ap (PQR) cell aberrantly migrated far into the anterior of the animal. | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0004096 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0004086 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0004993 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000470 | Paper_evidence | WBPaper00001105 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | HSNs fail to arrive at their final destination (between P5/6 and V4) | Paper_evidence | WBPaper00001105 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00001105 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00001105 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000505 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | reduced rays | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Person_evidence | WBPerson261 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000506 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | swollen bursa | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Person_evidence | WBPerson261 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000594 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Mig | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000631 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | variable drug response | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000695 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | possibly abnormal vulva | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000816 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | Approximately 50% of egl-27(n170) animals exhibited missing QL and/or QR neuroblasts at hatching (Table 1) | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Incomplete | 50% penetrant | Paper_evidence | WBPaper00003450 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0004056 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0004054 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00003450 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000828 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | egl-27(n170) mutants exhibited an abnormal pattern of T cell lineages, with all descendants of T adopting a hypodermal or hypodermal-like fate, unlike wild type (Figure 1). | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006994 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006996 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006995 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006997 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000862 | Paper_evidence | WBPaper00000635 | |||||||
Person_evidence | WBPerson261 | ||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson712 | |||||||||
Remark | variable bloating, moderate to severe; difficult to score (ES2) in adult | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Penetrance | Incomplete | variable | Paper_evidence | WBPaper00000635 | |||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0001068 | Paper_evidence | WBPaper00000635 | |||||||
Curator_confirmed | WBPerson48 | ||||||||
Penetrance | Incomplete | variable | Paper_evidence | WBPaper00000635 | |||||
Curator_confirmed | WBPerson48 | ||||||||
Phenotype_assay | Treatment | 5 mg/ml serotonin | Paper_evidence | WBPaper00000635 | |||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0001336 | Paper_evidence | WBPaper00000635 | |||||||
Curator_confirmed | WBPerson48 | ||||||||
Phenotype_assay | Treatment | As described in Hodgkin, Horvitz, and Brenner (1979), six L4 males and six L4 dpy-11 hermaphrodites incubated for 24 hours, males removed, and hermaphrodites transferred to fresh dishes each day. Cross-progeny are counted. | Paper_evidence | WBPaper00000635 | |||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0001340 | Paper_evidence | WBPaper00000635 | |||||||
Curator_confirmed | WBPerson48 | ||||||||
Penetrance | Incomplete | variable | Paper_evidence | WBPaper00000635 | |||||
Curator_confirmed | WBPerson48 | ||||||||
Phenotype_assay | Treatment | 0.75 mg/ml imipramine | Paper_evidence | WBPaper00000635 | |||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0002211 | Paper_evidence | WBPaper00003450 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | The egl-27(n170) mutation results in a completely penetrant phasmid dye filling defect, indicative of abnormal T cell polarity (Table 1). | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Complete | Paper_evidence | WBPaper00003450 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005425 | PATO:0000460 | Paper_evidence | WBPaper00003450 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
Reference | WBPaper00022356 | ||||||||
WBPaper00012673 | |||||||||
WBPaper00000635 | |||||||||
WBPaper00001105 | |||||||||
WBPaper00003450 | |||||||||
WBPaper00011766 | |||||||||
Method | Allele |