WormBase Tree Display for Variation: WBVar00089711

WBVar00089711 Name: Public_name: n728
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023624
      WBStrain00026864
      WBStrain00048146
    Laboratory: MT
    Status: Live
  Linked_to: WBVar02147482
  Affects: Gene: WBGene00001202
  Genetics: Mapping_data: In_2_point: 799
        6011
        6012
        6027
        6028
      In_multi_point: 730
        735
        751
        2010
        2011
        2267
        2268
        2273
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Semi_dominant: Paper_evidence: WBPaper00002305
          Curator_confirmed: WBPerson557
      WBPhenotype:0000007 Paper_evidence: WBPaper00000635
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: Some eggs laid. Paper_evidence: WBPaper00000635
            Curator_confirmed: WBPerson48
          50% adults form bag-of-worms Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Paper_evidence: WBPaper00000635
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson48
            WBPerson712
      WBPhenotype:0000022 Paper_evidence: WBPaper00002305
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson557
        Remark: Muscle activation defective (flaccid, long) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
      WBPhenotype:0000205 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Semi_dominant: Paper_evidence: WBPaper00002305
          Curator_confirmed: WBPerson557
      WBPhenotype:0000229 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Sma? Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
      WBPhenotype:0000340 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: insensitive to imipramine Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
      WBPhenotype:0000349 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Muscle activation defective (flaccid, long) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
      WBPhenotype:0000542 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0000644 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Remark: Flaccid paralysis. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
      WBPhenotype:0000862 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: severe bloating, n728/+ has similar phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000996 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Abnormal defecation (Exp) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
      WBPhenotype:0001005 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0001068 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
          WBPerson557
        Remark: insensitive to serotonin Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: 5 mg/ml serotonin Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            Animals placed in serotonin (10 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001101 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Remark: Animals resistant to egg laying caused by addition of clomipramine. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals placed in clomipramine (0.75 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001330 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
        Dominant: Paper_evidence: WBPaper00000914
          Curator_confirmed: WBPerson48
      WBPhenotype:0001336 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
      WBPhenotype:0001339 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Curator_confirmed: WBPerson48
          WBPerson557
        Remark: data not shown Paper_evidence: WBPaper00000635
            Curator_confirmed: WBPerson48
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: 0.1 mg/ml levamisole Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            Animals placed in levamisole (100 ug/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001340 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Curator_confirmed: WBPerson48
          WBPerson557
        Phenotype_assay: Treatment: 0.75 mg/ml imipramine Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            Animals placed in imipramine (0.75 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001341 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
        Remark: data not shown Paper_evidence: WBPaper00000635
            Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: 10 mg/ml phentolamine Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
      WBPhenotype:0002284 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002288 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002291 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002296 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002299 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002302 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002309 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002314 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002319 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002322 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002325 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002337 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002346 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002348 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0004022 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0001645 Paper_evidence: WBPaper00040284
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00040284
            Curator_confirmed: WBPerson2987
      WBPhenotype:0002535 Paper_evidence: WBPaper00060981
        Curator_confirmed: WBPerson712
        Remark: The dye analysis coupled with microscopy imaging revealed that similar to wild type, both egl-36 mutants fill up their ciliated sensory neurons with the lipophilic fluorescent dye (DiI), suggesting that egl-36 mutants have no gross cilia abnormalities in C. elegans (Figure 1E). Paper_evidence: WBPaper00060981
            Curator_confirmed: WBPerson712
  Reference (12)
  Remark: Variation stub/paper connection generated from the May 2021 NN VFP dataset.
    Created by WBPerson51134 from the NN_VFP_triage_pipeline
  Method: Allele