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WormBase Tree Display for Variation: WBVar00090705

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Name Class

WBVar00090705NamePublic_namen3419
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027424
LaboratoryMT
StatusLive
AffectsGeneWBGene00006562
DescriptionPhenotypeWBPhenotype:0000022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001101Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
Remarktdc-1 mutants blocked clozapine-induced egg laying. tdc-1 mutant showed no statistically significant increase in egg laying in response to clozapine compared to control conditions.Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003634Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002288Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002293Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002296Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002301Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002313Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002318Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002319Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002322Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002325Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002337Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002344Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002346Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002563Paper_evidenceWBPaper00058912
Curator_confirmedWBPerson2987
Remark"We therefore tested a deletion mutant of tdc-1, a tyrosine decarboxylase required for tyramine biosynthesis. These tdc-1 (n3419) mutants are strongly defective in tyramine production (Alkema et al., 2005). We also tested a large deletion allele of lgc-55 (Donnelly et al., 2013; Ringstad et al., 2009), a tyramine receptor that is expressed in the SMD neurons (Pirri et al., 2009)(Figure S6A). Both mutant strains were defective in the forward/reverse state modulation of SMDD frequency, but no other parameters (Figure S6B)."Paper_evidenceWBPaper00058912
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004972PATO:0000460Paper_evidenceWBPaper00058912
Curator_confirmedWBPerson2987
WBbt:0004971PATO:0000460Paper_evidenceWBPaper00058912
Curator_confirmedWBPerson2987
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000238Paper_evidenceWBPaper00035327
Curator_confirmedWBPerson2021
RemarkTyramine deficient tdc-1 mutants did not have significant roaming defectsPaper_evidenceWBPaper00035327
Curator_confirmedWBPerson2021
WBPhenotype:0001765Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
RemarkMutants defective in the synthesis and reception of nonessential excitatory neurotransmitters respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatment10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
ReferenceWBPaper00038382
WBPaper00043908
WBPaper00031936
WBPaper00035327
WBPaper00058912
WBPaper00065802
WBPaper00065715
MethodAllele