WormBase Tree Display for Variation: WBVar00000448
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WBVar00000448 | Evidence | Paper_evidence | WBPaper00032187 | |||||
---|---|---|---|---|---|---|---|---|
Mass_spec_evidence | ||||||||
Name | Public_name | bc374 | ||||||
Sequence_details | Mapping_target | Y11D7A | ||||||
Type_of_mutation | Deletion | |||||||
SeqStatus | Pending_curation | |||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00040237 | |||||||
Laboratory | MD | |||||||
Status | Live | |||||||
Affects | Gene | WBGene00012435 | ||||||
Interactor | WBInteraction000503773 | |||||||
WBInteraction000503774 | ||||||||
WBInteraction000503775 | ||||||||
WBInteraction000521962 | ||||||||
Isolation | Mutagen | EMS | Paper_evidence | WBPaper00032187 | ||||
Description | Phenotype | WBPhenotype:0000035 | Paper_evidence | WBPaper00040526 | ||||
Curator_confirmed | WBPerson712 | |||||||
Remark | flh-1(bc374) embryos that expressed higher flh-2 reporter levels early in development were more likely to develop into morphologically WT larvae. | Induction of the ptbx-8::GFP reporter did not predict the outcome of the flh-1(bc374) mutation. | Paper_evidence | WBPaper00040526 | |||||
Curator_confirmed | WBPerson712 | |||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00040526 | |||||
Curator_confirmed | WBPerson712 | |||||||
Variation_effect | Null | Paper_evidence | WBPaper00040526 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000520 | Paper_evidence | WBPaper00032187 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals exhibited nearly wild-type phenotype, but had a low penetrance of young larvae with morphological abnormalities. | Paper_evidence | WBPaper00032187 | |||||
Curator_confirmed | WBPerson712 | |||||||
Penetrance | Low | Paper_evidence | WBPaper00032187 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001236 | Paper_evidence | WBPaper00040526 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | flh-1(bc374) mutant embryos induced higher levels of a pflh-2::GFP reporter than WT embryos at comma stage. In contrast, no upregulation of a tbx-8 reporter was observed in an flh-1(bc374) background. | Paper_evidence | WBPaper00040526 | |||||
Curator_confirmed | WBPerson712 | |||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00040526 | |||||
Curator_confirmed | WBPerson712 | |||||||
Variation_effect | Null | Paper_evidence | WBPaper00040526 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001779 | Paper_evidence | WBPaper00032187 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Two-fold increases and decreases were detected for various miRNA's. Transcriptional GFP reporters and Northern blots using RNA from embryos showed precocious expression of lin-4, mir-48, mir-59, and mir-241. No alteration of post-embryonic temporal expression was observed. | Paper_evidence | WBPaper00032187 | |||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00040526 | |||||||
WBPaper00032187 | ||||||||
Remark | bc374 is a deletion that deletes most of exons 2 and 3 and results in the loss of the FLYWCH domain. | Paper_evidence | WBPaper00032187 | |||||
Method | Deletion_allele |