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WormBase Tree Display for Variation: WBVar00000448

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Name Class

WBVar00000448EvidencePaper_evidenceWBPaper00032187
Mass_spec_evidence
NamePublic_namebc374
Sequence_detailsMapping_targetY11D7A
Type_of_mutationDeletion
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00040237
LaboratoryMD
StatusLive
AffectsGeneWBGene00012435
InteractorWBInteraction000503773
WBInteraction000503774
WBInteraction000503775
WBInteraction000521962
IsolationMutagenEMSPaper_evidenceWBPaper00032187
DescriptionPhenotypeWBPhenotype:0000035Paper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
Remarkflh-1(bc374) embryos that expressed higher flh-2 reporter levels early in development were more likely to develop into morphologically WT larvae. | Induction of the ptbx-8::GFP reporter did not predict the outcome of the flh-1(bc374) mutation.Paper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00032187
Curator_confirmedWBPerson712
RemarkAnimals exhibited nearly wild-type phenotype, but had a low penetrance of young larvae with morphological abnormalities.Paper_evidenceWBPaper00032187
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00032187
Curator_confirmedWBPerson712
WBPhenotype:0001236Paper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
Remarkflh-1(bc374) mutant embryos induced higher levels of a pflh-2::GFP reporter than WT embryos at comma stage. In contrast, no upregulation of a tbx-8 reporter was observed in an flh-1(bc374) background.Paper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00040526
Curator_confirmedWBPerson712
WBPhenotype:0001779Paper_evidenceWBPaper00032187
Curator_confirmedWBPerson712
RemarkTwo-fold increases and decreases were detected for various miRNA's. Transcriptional GFP reporters and Northern blots using RNA from embryos showed precocious expression of lin-4, mir-48, mir-59, and mir-241. No alteration of post-embryonic temporal expression was observed.Paper_evidenceWBPaper00032187
Curator_confirmedWBPerson712
ReferenceWBPaper00040526
WBPaper00032187
Remarkbc374 is a deletion that deletes most of exons 2 and 3 and results in the loss of the FLYWCH domain.Paper_evidenceWBPaper00032187
MethodDeletion_allele