WormBase Tree Display for Variation: WBVar00051372
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| WBVar00051372 | Name | Public_name | cc450 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00030622 | ||||||||
| Laboratory | PD | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00001948 | |||||||
| Genetics | Mapping_data | In_pos_neg_data | 7097 | ||||||
| 7103 | |||||||||
| 7109 | |||||||||
| 7115 | |||||||||
| 7136 | |||||||||
| 7140 | |||||||||
| 7142 | |||||||||
| Description | Phenotype | WBPhenotype:0000062 | Person_evidence | WBPerson261 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | recessive lethal, arrest at varying stages as lumpy dumpy with some muscle differentiation, disorganized myofilaments. Encodes member of MyoD family. Transcripts present transiently in MS descendants, stably in D daughters and C and MS lineages leading to body wall muscle. Antibody staining similar (nuclear staining, persists through development of body wall muscle cells) | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000861 | Paper_evidence | WBPaper00025033 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "Hermaphrodites heterozygous for the balanced hlh-1(cc450) null allele (Chen et al., 1992) were treated with mex-3, pop-1 double RNAi and progeny embryos collected. If HLH-1 was required for PAL-1 to induce muscle, 25% of the embryos (corresponding to the homozygous hlh-1(cc450) animals) should not respond to PAL-1. However, all treated embryos resulted in widespread body wall muscle-like myogenesis demonstrating that HLH-1 activity was not required for PAL-1-induced myogenesis (Fig. 7). We did notice that 22% (n=196) of the embryos showed less robust myogenesis, based on MHC A filament formation (Fig. 7B)." | Paper_evidence | WBPaper00025033 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00025033 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| GO_term | GO:0007525 | PATO:0000460 | Paper_evidence | WBPaper00025033 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Genotype | mex-3, pop-1 double RNAi | Paper_evidence | WBPaper00025033 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000867 | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | arrest at varying stages as lumpy dumpy with some muscle differentiation, disorganized myofilaments. Encodes member of MyoD family. Transcripts present transiently in MS descendants, stably in D daughters and C and MS lineages leading to body wall muscle. Antibody staining similar (nuclear staining, persists through development of body wall muscle cells) | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000306 | Paper_evidence | WBPaper00003620 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | The pattern of ACE-2::GFP expression was similar to that observed in wild-type animals. | Paper_evidence | WBPaper00003620 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Reference | WBPaper00003620 | ||||||||
| WBPaper00015606 | |||||||||
| WBPaper00015045 | |||||||||
| WBPaper00015143 | |||||||||
| WBPaper00025033 | |||||||||
| Method | Allele |
