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WormBase Tree Display for Variation: WBVar00087760

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Name Class

WBVar00087760EvidencePaper_evidenceWBPaper00024329
NamePublic_namehc52
Other_namehc52ts
C17D12.6a.1:c.1649G>A
CE42755:p.Gly269Glu
C17D12.6b.1:c.806G>A
CE27074:p.Gly550Glu
HGVSgCHROMOSOME_I:g.11583193C>T
Sequence_detailsSMapS_parentSequenceC17D12
Flanking_sequencestcgttcttttcagctgtcaatgcgtcaatggacacgtggctcgttgtgtgagaatgtgga
Mapping_targetC17D12
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00024329
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000379
LaboratoryBA
StatusLive
AffectsGeneWBGene00004963
TranscriptC17D12.6a.1 (12)
C17D12.6b.1 (12)
GeneticsInterpolated_map_positionI9.26839
Mapping_dataIn_multi_point3106
DescriptionPhenotypeWBPhenotype:0000357Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Phenotype_assayTemperature16C, 25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
WBPhenotype:0000389Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkHermaphrodites grown at 25C produce motile sperm that are fertilization defective. Self-fertility < 1% (25C) 100% (16C).Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000693Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMales grown at 25C produce motile sperm that are fertilization defective.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000736Paper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
RemarkIn spe-9(hc52ts) mutant eggs, the first induction of GFP-LGG-1-positive autophagosomes was not observed.Paper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
WBPhenotype:0001135Paper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
RemarkPaternal mitochondria persisted.Paper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
WBPhenotype:0001360Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Phenotype_assayTemperature16C, 25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
WBPhenotype:0001375Paper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
RemarkIn spe-9(hc52ts) mutant eggs, the first induction of GFP-LGG-1-positive autophagosomes was not observed.Paper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00040312
Curator_confirmedWBPerson712
WBPhenotype:0001720Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RemarkSpermatozoa are slowly swept out of the spermatheca by passing oocytesPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Phenotype_assayTemperature16C, 25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000306Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
RemarkCAV-1::GFP degradation had normal kinetics in unfertilized eggs. Authors report identical results with CAV-2::GFP.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Phenotype_assayTreatmentL4 hermaphrodites were incubated at 25C for 24 hr then examined under fluorescence.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Temperature25CPaper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
GenotypepwIs281Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
WBPhenotype:0000390Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RemarkAdults produce large numbers of spermatids that activate in vitro after pronase treatment to form spermatozoa that are cytologically indistinguishable from wild typePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Phenotype_assayTemperature16C, 25CPaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
WBPhenotype:0001323Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
RemarkCAV-1 body formation normal in oocytes as assayed by CAV-1::GFP fluorescence. Authors report identical results with CAV-2::GFP.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Phenotype_assayTreatmentL4 hermaphrodites were incubated at 25C for 24 hr then examined under fluorescence.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Temperature25CPaper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
GenotypepwIs281Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
ReferenceWBPaper00040312
WBPaper00027612
WBPaper00001075
MethodSubstitution_allele