WormBase Tree Display for Variation: WBVar00087769

WBVar00087769 Name: Public_name: hc62
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026552
    Laboratory: BA
    Status: Live
  Affects: Gene: WBGene00019630
    Interactor: WBInteraction000500097
      WBInteraction000518185
      WBInteraction000518312
      WBInteraction000518313
      WBInteraction000518314
      WBInteraction000518315
      WBInteraction000518316
      WBInteraction000518317
      WBInteraction000518318
      WBInteraction000518319
  Genetics: Mapping_data: In_multi_point: 300
  Description: Phenotype: WBPhenotype:0000070 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: Hemizygotes up-shifted to 24 at the L1 larval stage exhibited additional male tail defects. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00039858
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: emb-1(hc62ts)/sDf121 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
      WBPhenotype:0000360 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: defective cytoplasmic streaming; similar phenotype to hc57 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00039858
                Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 24 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
        Maternal
      WBPhenotype:0001100 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: At 25C one to 24 cell arrest, normal and defective execution before one cell stage. Viable at 16C. Similar phenotype to hc57. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0007833 PATO:0001422 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000004 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001168 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: no pseudocleavage; similar phenotype to hc57 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001216 Paper_evidence: WBPaper00039858
          WBPaper00004484
        Curator_confirmed: WBPerson712
          WBPerson205
        Remark: emb-1 mutants arrest at metaphase of meiosis I. | emb-1 animals expressing a maternally expressed tubulin::GFP transgene accumulate meiotic one-cell embryos with barrel-shaped meiotic spindles. | emb-1 homozygotes had elevated numbers of pHisH3 (M-phase) staining germline nuclei even when maintained at the permissive temperature of 16. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        Rescued_by_transgene: WBTransgene00015151
        Temperature_sensitive: Heat_sensitive: 24 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
        Maternal
        Phenotype_assay: Genotype: unc-42; lon-1 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000688 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: The mutant defects are maternal specific as emb-1(hc62ts) males are fertile. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00039858
                Curator_confirmed: WBPerson712
  Reference: WBPaper00039858
    WBPaper00004484
    WBPaper00016048
  Method: Allele