WormBase Tree Display for Variation: WBVar00088007

WBVar00088007 Evidence: Paper_evidence: WBPaper00001109
  Name: Public_name: it26
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023559
    Laboratory: KK
    Status: Live
  Affects: Gene: WBGene00003196
    Interactor: WBInteraction000009266
      WBInteraction000521252
      WBInteraction000521253
      WBInteraction000521254
      WBInteraction000521255
      WBInteraction000521256
      WBInteraction000534747
      WBInteraction000534748
  Genetics: Mapping_data: In_pos_neg_data: 4481
  Description: Phenotype: WBPhenotype:0000052 Paper_evidence: WBPaper00003517
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: maternal effect embryonic lethal, extensive zygotic rescue Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          mel-11(it26) is ts for hatching, with a fully penetrant Mel phenotype at 25C. it26 fails to complement sb55 for Mel. Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00003517
          Curator_confirmed: WBPerson712
        Variation_effect: Loss_of_function_undetermined_extent: Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-4(e120) sqt-1(sc13) Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
      WBPhenotype:0000409 Paper_evidence: WBPaper00003517
        Curator_confirmed: WBPerson712
        Remark: Initially, embryos that are blocked at the 1.5-fold stage (18/34 animals) resemble elongation-defective embryos characteristic of strong let-502 mutations (Wissmann et al., 1997). Soon thereafter, these embryos either adopt a somewhat compressed appear- ance or extrude internal cells at variable positions along the ventral midline. Embryos that elongate to the 2-fold stage (13/34) often show an apparent hypercontraction in the middle to posterior of the embryo. This results in a tail with a crumpled appearance, and these embryos frequently rupture along the ventral midline. Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00003517
          Curator_confirmed: WBPerson712
        Variation_effect: Loss_of_function_undetermined_extent: Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-4(e120) sqt-1(sc13) Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
      WBPhenotype:0000864 Paper_evidence: WBPaper00003517
        Curator_confirmed: WBPerson712
        Remark: The majority of mel-11(it26) embryos raised at the nonpermissive temperature arrest between the 1.5- and 2-fold stages of elongation (31/34 animals). Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00003517
          Curator_confirmed: WBPerson712
        Variation_effect: Loss_of_function_undetermined_extent: Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-4(e120) sqt-1(sc13) Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
      WBPhenotype:0000867 Paper_evidence: WBPaper00032115
        Curator_confirmed: WBPerson712
        Remark: Embryos arrest during elongation and are hypercontractile. Paper_evidence: WBPaper00032115
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00032115
                Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000688 Paper_evidence: WBPaper00003517
        Curator_confirmed: WBPerson712
        Remark: it26 retains near-normal Ste activity; the brood sizes of it26 hermaphrodites are near normal at all temperatures. it26 fully complements sb55 for Ste. Paper_evidence: WBPaper00003517
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00003517
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-4(e120) sqt-1(sc13) Paper_evidence: WBPaper00003517
              Curator_confirmed: WBPerson712
  Reference: WBPaper00017345
    WBPaper00017369
    WBPaper00032115
    WBPaper00003517
  Method: Allele