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WormBase Tree Display for Variation: WBVar00088502

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Name Class

WBVar00088502EvidencePaper_evidenceWBPaper00031667
NamePublic_namelj22
Other_nameCE52634:p.Arg54Cys
T23F2.13.1:c.160C>T
HGVSgCHROMOSOME_X:g.5493198C>T
Sequence_detailsSMapS_parentSequenceT23F2
Flanking_sequencesgtcccactttctctcgttatctggttcgttgtcgtgagctttgtaccgaaacttccgtcg
Mapping_targetT23F2
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00031667
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000207
WBStrain00004743
WBStrain00004744
WBStrain00004764
LaboratoryAQ
StatusLive
AffectsGeneWBGene00044623
WBGene00303081
TranscriptT23F2.13.1 (12)
GeneticsInterpolated_map_positionX-5.24324
DescriptionPhenotypeWBPhenotype:0000010Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
RemarkAnimals show enhanced sensitivity to drugs of a variety of sizes and structures.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Phenotype_assayTreatmentGravid hermaphrodites were placed into wells (of 96-well plates) containing the compound. Sensitivity was assessed based on the time until paralysis ensued. Concentrations of the compounds are as follows: Nicotine, 0.1%v/v in M9; 1-Phenoxypropan-2-ol , 0.1% or 0.5% in M9; Ivermectin dissolved in DMSO and diluted to 2.5ug/ml in M9.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
WBPhenotype:0000054Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
RemarkAnimals show significant larval lethality.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Phenotype_assayTemperature22.5Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
WBPhenotype:0001202Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Phenotype_assayTreatmentGravid hermaphrodites were placed into wells (of 96-well plates) containing the compound. Sensitivity was assessed based on the time until paralysis ensued. Concentrations of the compounds are as follows: Nicotine, 0.1%v/v in M9.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
WBPhenotype:0001209Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
RemarkAnimals are Unc.Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
WBPhenotype:0001413Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000050Paper_evidenceWBPaper00031667
Curator_confirmedWBPerson712
ReferenceWBPaper00031667
RemarkManually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00044623 UTR_5Paper_evidenceWBPaper00031667
MethodSubstitution_allele