WormBase Tree Display for Variation: WBVar00088948

WBVar00088948 Evidence: Paper_evidence: WBPaper00032966
  Name: Public_name: mg360
    Other_name: F29C12.3b.1:c.3206G>A
      F29C12.3a.1:c.3200G>A
      F29C12.3c.1:c.770G>A
      CE45435:p.Gly1069Glu
      CE43301:p.Gly1067Glu
      CE45505:p.Gly257Glu
    HGVSg: CHROMOSOME_II:g.13104077C>T
  Sequence_details: SMap: S_parent: Sequence: F29C12
    Flanking_sequences: aggcgagcctgctggcagtatcaagtatcg aagcacagatggtggatttgagatccttccc
    Mapping_target: F29C12
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00032966
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023647
    Laboratory: GR
    Status: Live
  Affects: Gene: WBGene00009245
    Transcript: F29C12.3b.1 (12)
      F29C12.3c.1 (12)
      F29C12.3a.1 (12)
    Interactor: WBInteraction000524975
      WBInteraction000524976
      WBInteraction000524977
      WBInteraction000524978
      WBInteraction000524979
      WBInteraction000524980
      WBInteraction000524981
      WBInteraction000524982
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: II 14.2761
  Description: Phenotype: WBPhenotype:0000128 Paper_evidence: WBPaper00053668
        Curator_confirmed: WBPerson31364
        Remark: animals show increased rates of dauer formation at 27°C but not 25°C in the absence of pheromone. Paper_evidence: WBPaper00053668
            Curator_confirmed: WBPerson31364
      WBPhenotype:0000130 Paper_evidence: WBPaper00053668
        Curator_confirmed: WBPerson31364
        Remark: animals display increased rates of dauer formation in the presence of ascr#5 pheromone Paper_evidence: WBPaper00053668
            Curator_confirmed: WBPerson31364
      WBPhenotype:0000154 Paper_evidence: WBPaper00032966
        Curator_confirmed: WBPerson2021
        Remark: lpo-6 animals produced 40% fewer progeny than wild-type Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032966
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000164 Paper_evidence: WBPaper00032966
        Person_evidence: WBPerson6788
        Curator_confirmed: WBPerson2021
        Remark: Thin Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: Paper_evidence: WBPaper00032966
              Person_evidence: WBPerson6788
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032966
          Person_evidence: WBPerson6788
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000229 Paper_evidence: WBPaper00032966
        Person_evidence: WBPerson6788
        Curator_confirmed: WBPerson2021
        Remark: Small Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
          lpo-6 mutants displayed decreased adult body size Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: Paper_evidence: WBPaper00032966
              Person_evidence: WBPerson6788
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032966
          Person_evidence: WBPerson6788
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
          Hypomorph_reduction_of_function: Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00032966
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000848 Paper_evidence: WBPaper00032966
        Person_evidence: WBPerson6788
        Curator_confirmed: WBPerson2021
        Remark: Developmental delay Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
          lpo-6 mutants displayed slight developmental delay Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: Paper_evidence: WBPaper00032966
              Person_evidence: WBPerson6788
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032966
          Person_evidence: WBPerson6788
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
          Hypomorph_reduction_of_function: Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001184 Paper_evidence: WBPaper00032966
        Person_evidence: WBPerson6788
        Curator_confirmed: WBPerson2021
        Remark: Increased fat Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
          The excess fat accumulation of lpo-6 (mg360) mutants was associated with enlarged lipid-storing subcellular particles throughout intestinal cells, as well as an overall increase in Nile Red fluorescence and by staining with other lipid dyesfatty acid conjugated BODIPY and the fixed stain Sudan Black Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: Paper_evidence: WBPaper00032966
              Person_evidence: WBPerson6788
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032966
          Person_evidence: WBPerson6788
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
          Hypomorph_reduction_of_function: Paper_evidence: WBPaper00032966
            Person_evidence: WBPerson6788
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Altered Nile Red staining Paper_evidence: WBPaper00032966
              Person_evidence: WBPerson6788
              Curator_confirmed: WBPerson2021
            Nile Red staining, BODIPY staining and the fixed stain Sudan Black Paper_evidence: WBPaper00032966
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001278 Paper_evidence: WBPaper00053668
        Curator_confirmed: WBPerson31364
        Remark: animals display reduced ASI expression of daf-7p::GFP (ksIs2) at 27°C Paper_evidence: WBPaper00053668
            Curator_confirmed: WBPerson31364
      WBPhenotype:0001462 Paper_evidence: WBPaper00051289
        Curator_confirmed: WBPerson10274
        Remark: Figure 3B Paper_evidence: WBPaper00051289
            Curator_confirmed: WBPerson10274
    Phenotype_not_observed: WBPhenotype:0001006 Paper_evidence: WBPaper00032966
        Curator_confirmed: WBPerson2021
        Remark: The pumping rate of lpo-6 (mg360) animals was indistinguishable from that of wild-type animals under well-fed conditions Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032966
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032966
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00032966
    WBPaper00051289
    WBPaper00053668
  Method: Substitution_allele