WormBase Tree Display for Variation: WBVar00088992

WBVar00088992 Name: Public_name: mh15
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00024028
    Laboratory: KS
    Status: Live
  Affects: Gene: WBGene00006561
    Interactor: WBInteraction000538569
      WBInteraction000538570
      WBInteraction000538571
      WBInteraction000538573
      WBInteraction000538576
      WBInteraction000538577
      WBInteraction000538578
  Genetics: Mapping_data: In_multi_point: 4870
  Description: Phenotype: WBPhenotype:0000038 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Penetrance: Low: 3 Paper_evidence: WBPaper00005832
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000099 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: "Specifically, 7% (n = 42) of tcl-2(mh15) hermaphrodites were missing Pn.p cells, and 21% displayed extra Pn.p divisions; among those tcl-2(mh15) mutants with normal Pn.p numbers, 13% (n = 30; Table 2) had a P11.p-like cell in the position of P12.pa cell and 7% had two P12.pa like cells, suggesting that both P12.p-to-P11.p and P11.p-to-P12.p cell fate transformations occur in tcl-2 mutants." Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006899 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
            WBbt:0006900 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000414 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: "Specifically, 7% (n = 42) of tcl-2(mh15) hermaphrodites were missing Pn.p cells, and 21% displayed extra Pn.p divisions; among those tcl-2(mh15) mutants with normal Pn.p numbers, 13% (n = 30; Table 2) had a P11.p-like cell in the position of P12.pa cell and 7% had two P12.pa like cells, suggesting that both P12.p-to-P11.p and P11.p-to-P12.p cell fate transformations occur in tcl-2 mutants." Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006899 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
            WBbt:0006900 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000697 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: 15 Paper_evidence: WBPaper00005832
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000828 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: "Analysis of the T cell lineages showed that the fates of the T.a and T.p cells were variably defective in each tcl-2 mutant (Fig. 1B)." Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004946 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
            WBbt:0004944 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001355 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: "Each tcl-2 allele caused a gonad defect. The os14, os40, and n3170 mutants displayed a similar and more penetrant defect than did mh15 (Table 2)." Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Penetrance: Low: 7 Paper_evidence: WBPaper00005832
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0005175 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0002174 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: "Specifically, 7% (n = 42) of tcl-2(mh15) hermaphrodites were missing Pn.p cells, and 21% displayed extra Pn.p divisions; among those tcl-2(mh15) mutants with normal Pn.p numbers, 13% (n = 30; Table 2) had a P11.p-like cell in the position of P12.pa cell and 7% had two P12.pa like cells, suggesting that both P12.p-to-P11.p and P11.p-to-P12.p cell fate transformations occur in tcl-2 mutants." Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Penetrance: Low: 7 Paper_evidence: WBPaper00005832
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006899 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
            WBbt:0006900 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0002175 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: "Specifically, 7% (n = 42) of tcl-2(mh15) hermaphrodites were missing Pn.p cells, and 21% displayed extra Pn.p divisions; among those tcl-2(mh15) mutants with normal Pn.p numbers, 13% (n = 30; Table 2) had a P11.p-like cell in the position of P12.pa cell and 7% had two P12.pa like cells, suggesting that both P12.p-to-P11.p and P11.p-to-P12.p cell fate transformations occur in tcl-2 mutants." Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: 21 Paper_evidence: WBPaper00005832
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006899 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
            WBbt:0006900 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
      WBPhenotype:0002211 Paper_evidence: WBPaper00005832
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00005832
            Curator_confirmed: WBPerson2987
        Penetrance: Complete: 100 Paper_evidence: WBPaper00005832
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00005832
          Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0005425 PATO:0000460 Paper_evidence: WBPaper00005832
                Curator_confirmed: WBPerson2987
  Reference: WBPaper00005832
  Method: Allele