WormBase Tree Display for Variation: WBVar00088993
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WBVar00088993 | Evidence | Paper_evidence | WBPaper00017744 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | mh17 | |||||||
Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00024031 | ||||||||
Laboratory | KS | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00006580 | |||||||
Interactor | WBInteraction000001626 | ||||||||
WBInteraction000524650 | |||||||||
WBInteraction000535540 | |||||||||
Description | Phenotype | WBPhenotype:0000070 | Paper_evidence | WBPaper00005188 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Interestingly, the tail tips in these mutants seem to differentiate fan cuticle, as excess cuticle surrounds the pointy tail tip, unlike lep-1 mutants (Nguyen et. al, 1999). Regions of the fan are often narrow and misshapen." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005741 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000297 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "In a few animals we observed fusions of rays 3 and 4 or 4 and 5 and an ectopic T cell-derived ray." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006948 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006949 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006950 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000350 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Gross morphologies of the tail tips of tlp-1 hermaphrodites are unaffected, although there are often defects at the cellular level (see below)." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006979 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000495 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "In a few animals we observed fusions of rays 3 and 4 or 4 and 5 and an ectopic T cell-derived ray." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006941 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000828 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Analysis of the T cell lineages of each tlp-1 mutant showed that cell fates of the posterior T cell daughter, T.p, and the posterior daughter of the T.ap cell, T.app, were variably defective (Fig 1). We observed four basic patterns of defective cell lineages from which we conclude that tlp-1 mutations cause a loss of asymmetry in the divisions of the T.p and T.ap cells, most often resulting in the loss of cell divisions and neural cell fates (Fig 1B)." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006996 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006997 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0007011 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0007015 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001225 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | Table 1; "A transgene in which gfp was fused in frame with tlp-1 and whose expression was designed to be driven by the tlp-1 promoter rescued the T cell defect but not the Lep defects of tlp-1 mutants (Table 1)." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Incomplete | 54 | Paper_evidence | WBPaper00005188 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Rescued_by_transgene | WBTransgene00006655 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0008410 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001431 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "To further understand male tail morphogenesis and tail tip cell retraction, we have isolated mutations that result in a leptoderan (Lep) male tail. The leptoderan tails of bx85 males, as well as those of ny14 and mh17, are prominent and variable in length (Fig 2). The Lep defect is completely penetrant in all three tlp-1 mutant alleles (Table 1)." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Complete | 100 | Paper_evidence | WBPaper00005188 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Recessive | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001509 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "In addition, rays 8 and 9 (60% of sides, n=58) or 7-9 (17% of sides) were often missing, consistent with the T cell lineage defects we observed." | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006952 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006953 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006954 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001968 | Paper_evidence | WBPaper00035069 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
Penetrance | Complete | Paper_evidence | WBPaper00035069 | ||||||
Curator_confirmed | WBPerson557 | ||||||||
Phenotype_assay | Temperature | 20 | Paper_evidence | WBPaper00035069 | |||||
Curator_confirmed | WBPerson557 | ||||||||
WBPhenotype:0002211 | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Screens for additional mutations that resulted in phasmid dye-filling (Pdy) defects resulted in the identification of the mh17 allele of tlp-1. In addition, separate screens for mutations that caused male tail defects yielded two additional tlp-1 alleles, bx85 and ny14, which also display phasmid dye-filling defects (Table 1). Both the Pdy and Lep defects are recessive. The penetrances of the Pdy defect of mh17 and bx85 mutations are similar but ny14 is more penetrant, although this may not be due to the removal of tlp-1 function alone... A transgene in which gfp was fused in frame with tlp-1 and whose expression was designed to be driven by the tlp-1 promoter rescued the T cell defect but not the Lep defects of tlp-1 mutants (Table 1). " | Paper_evidence | WBPaper00005188 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Incomplete | 81 | Paper_evidence | WBPaper00005188 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Recessive | Paper_evidence | WBPaper00005188 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Rescued_by_transgene | WBTransgene00006655 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005425 | PATO:0000460 | Paper_evidence | WBPaper00005188 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
Reference | WBPaper00017744 | ||||||||
WBPaper00035069 | |||||||||
WBPaper00005188 | |||||||||
Method | Allele |