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WormBase Tree Display for Variation: WBVar00088993

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Name Class

WBVar00088993EvidencePaper_evidenceWBPaper00017744
NamePublic_namemh17
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00024031
LaboratoryKS
StatusLive
AffectsGeneWBGene00006580
InteractorWBInteraction000001626
WBInteraction000524650
WBInteraction000535540
DescriptionPhenotypeWBPhenotype:0000070Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"Interestingly, the tail tips in these mutants seem to differentiate fan cuticle, as excess cuticle surrounds the pointy tail tip, unlike lep-1 mutants (Nguyen et. al, 1999). Regions of the fan are often narrow and misshapen."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005741PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0000297Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"In a few animals we observed fusions of rays 3 and 4 or 4 and 5 and an ectopic T cell-derived ray."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006948PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0006949PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0006950PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0000350Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"Gross morphologies of the tail tips of tlp-1 hermaphrodites are unaffected, although there are often defects at the cellular level (see below)."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006979PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0000495Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"In a few animals we observed fusions of rays 3 and 4 or 4 and 5 and an ectopic T cell-derived ray."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006941PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0000828Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"Analysis of the T cell lineages of each tlp-1 mutant showed that cell fates of the posterior T cell daughter, T.p, and the posterior daughter of the T.ap cell, T.app, were variably defective (Fig 1). We observed four basic patterns of defective cell lineages from which we conclude that tlp-1 mutations cause a loss of asymmetry in the divisions of the T.p and T.ap cells, most often resulting in the loss of cell divisions and neural cell fates (Fig 1B)."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006996PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0006997PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0007011PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0007015PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0001225Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
RemarkTable 1; "A transgene in which gfp was fused in frame with tlp-1 and whose expression was designed to be driven by the tlp-1 promoter rescued the T cell defect but not the Lep defects of tlp-1 mutants (Table 1)."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
PenetranceIncomplete54Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Rescued_by_transgeneWBTransgene00006655
EQ_annotationsAnatomy_termWBbt:0008410PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0001431Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"To further understand male tail morphogenesis and tail tip cell retraction, we have isolated mutations that result in a leptoderan (Lep) male tail. The leptoderan tails of bx85 males, as well as those of ny14 and mh17, are prominent and variable in length (Fig 2). The Lep defect is completely penetrant in all three tlp-1 mutant alleles (Table 1)."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
PenetranceComplete100Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
RecessivePaper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0001509Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"In addition, rays 8 and 9 (60% of sides, n=58) or 7-9 (17% of sides) were often missing, consistent with the T cell lineage defects we observed."Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006952PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0006953PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBbt:0006954PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
WBPhenotype:0001968Paper_evidenceWBPaper00035069
Curator_confirmedWBPerson557
PenetranceCompletePaper_evidenceWBPaper00035069
Curator_confirmedWBPerson557
Phenotype_assayTemperature20Paper_evidenceWBPaper00035069
Curator_confirmedWBPerson557
WBPhenotype:0002211Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Remark"Screens for additional mutations that resulted in phasmid dye-filling (Pdy) defects resulted in the identification of the mh17 allele of tlp-1. In addition, separate screens for mutations that caused male tail defects yielded two additional tlp-1 alleles, bx85 and ny14, which also display phasmid dye-filling defects (Table 1). Both the Pdy and Lep defects are recessive. The penetrances of the Pdy defect of mh17 and bx85 mutations are similar but ny14 is more penetrant, although this may not be due to the removal of tlp-1 function alone... A transgene in which gfp was fused in frame with tlp-1 and whose expression was designed to be driven by the tlp-1 promoter rescued the T cell defect but not the Lep defects of tlp-1 mutants (Table 1). "Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
PenetranceIncomplete81Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
RecessivePaper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
Rescued_by_transgeneWBTransgene00006655
EQ_annotationsAnatomy_termWBbt:0005425PATO:0000460Paper_evidenceWBPaper00005188
Curator_confirmedWBPerson2987
ReferenceWBPaper00017744
WBPaper00035069
WBPaper00005188
MethodAllele