WormBase Tree Display for Variation: WBVar00090287
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| WBVar00090287 | Evidence | Paper_evidence | WBPaper00025002 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Public_name | n1892 | |||||||
| Sequence_details | Mapping_target | C48B4 | |||||||
| SeqStatus | Pending_curation | ||||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain (17) | |||||||||
| Laboratory | MT | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00000421 | |||||||
| Interactor | WBInteraction000052288 | ||||||||
| WBInteraction000052380 | |||||||||
| WBInteraction000052382 | |||||||||
| WBInteraction000502044 | |||||||||
| WBInteraction000517317 | |||||||||
| WBInteraction000518534 | |||||||||
| WBInteraction000557033 | |||||||||
| Genetics | Mapping_data | In_multi_point | 1726 | ||||||
| 1727 | |||||||||
| 1728 | |||||||||
| 1729 | |||||||||
| 1730 | |||||||||
| 1731 | |||||||||
| 1732 | |||||||||
| 1734 | |||||||||
| 1736 | |||||||||
| Description | Phenotype | WBPhenotype:0000241 | Paper_evidence | WBPaper00005874 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0003681 | PATO:0000460 | Paper_evidence | WBPaper00005874 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00005874 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000243 | Paper_evidence | WBPaper00050421 | |||||||
| Person_evidence | WBPerson261 | ||||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPerson2987 | |||||||||
| Remark | killer cells fail to engulf target cells; engulfment group A (ced-1,6,7); extensive maternal rescue | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| persistent corpses in the pharynx of L1 (Supplemental Table 1) | Paper_evidence | WBPaper00050421 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Variation_effect | Predicted_null_via_sequence | Paper_evidence | WBPaper00050421 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0003681 | PATO:0000460 | Paper_evidence | WBPaper00050421 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00050421 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Maternal | With_maternal_effect | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000885 | Paper_evidence | WBPaper00001438 | |||||||
| WBPaper00038317 | |||||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPerson712 | |||||||||
| Remark | Failure to engulf cell corpses | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Persistent cell corpses accumulate. | Paper_evidence | WBPaper00038317 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | Complete | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001438 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0005739 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBbt:0003681 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBbt:0005829 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBbt:0003666 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00001438 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBls:0000027 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBls:0000037 | PATO:0000460 | Paper_evidence | WBPaper00001438 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Maternal | |||||||||
| WBPhenotype:0001172 | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | programmed cell deaths abnormal, dying cells arrest at highly refractile stage; extensive maternal rescue | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Maternal | With_maternal_effect | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000520 | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | no gross phenotype | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Maternal | With_maternal_effect | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001208 | Paper_evidence | WBPaper00027644 | |||||||
| Curator_confirmed | WBPerson557 | ||||||||
| Remark | Animals were not resistant to RNAi as assayed on either pop-1 RNAi or unc-22 RNAi. | Paper_evidence | WBPaper00027644 | ||||||
| Curator_confirmed | WBPerson557 | ||||||||
| Phenotype_assay | Treatment | Animals reared on both pop-1 and unc-22 feeding plates at 15, 20, 25, and 26C. | Paper_evidence | WBPaper00027644 | |||||
| Curator_confirmed | WBPerson557 | ||||||||
| WBPhenotype:0002486 | Paper_evidence | WBPaper00050421 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "Mutations in genes within the ced-1/6/7 pathway (ced-1, ced-7, nrf-5, ttr-52), the ced-2/5/12 pathway (ced-2, ced-5), or both pathways (ced-1;ced-2 and ced-7;ced-5) did not cause PGC lobes to persist in L1 larvae (Supplementary Table 1), indicating that ced-10 functions in PGC lobe scission in a different context than it does in cell corpse engulfment." (PGC = 'primordial germ cell') | Paper_evidence | WBPaper00050421 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Variation_effect | Predicted_null_via_sequence | Paper_evidence | WBPaper00050421 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0004576 | PATO:0000460 | Paper_evidence | WBPaper00050421 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0004575 | PATO:0000460 | Paper_evidence | WBPaper00050421 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00050421 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Treatment | All strains include the xnIs360 or xnSi1 transgenes to visualize PGC membranes. | Paper_evidence | WBPaper00050421 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Reference | WBPaper00038317 | ||||||||
| WBPaper00001438 | |||||||||
| WBPaper00015205 | |||||||||
| WBPaper00021737 | |||||||||
| WBPaper00005874 | |||||||||
| WBPaper00011043 | |||||||||
| WBPaper00027644 | |||||||||
| WBPaper00015476 | |||||||||
| WBPaper00050421 | |||||||||
| Remark | Allele not identified (no protein detected by Western blot) | Paper_evidence | WBPaper00025002 | ||||||
| Method | Allele |
