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WormBase Tree Display for Variation: WBVar00090544

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Name Class

WBVar00090544EvidencePaper_evidenceWBPaper00002151
NamePublic_namen2678
Other_nameY54E10BL.6.1:c.637G>A
CE25437:p.Asp213Asn
HGVSgCHROMOSOME_I:g.3008805C>T
Sequence_detailsSMapS_parentSequenceY54E10BL
Flanking_sequencesgtcaatagtaacggagaaattaaattatgcattttggagtctctggaatgttgattgatt
Mapping_targetY54E10BL
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00002151
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027334
LaboratoryMT
StatusLive
AffectsGeneWBGene00003186
TranscriptY54E10BL.6.1 (12)
InteractorWBInteraction000519063
WBInteraction000556850
WBInteraction000556856
WBInteraction000556859
IsolationMutagenEMSPaper_evidenceWBPaper00002151
GeneticsInterpolated_map_positionI-5.23678
Mapping_dataIn_multi_point3202
3204
DescriptionPhenotypeWBPhenotype:0000146Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Remark"To assess the involvement of the Raf pathway in temperature memory variability in AFD, we analyzed temperature-evoked calcium dynamics of AFD in the Raf pathway mutants: lin-45, mek-2, mpk-1, and sur-2. Surprisingly, mutations in Raf pathway genes reduced the variability of response temperatures of AFD. The wild-type response temperatures distributed within a temperature range of about 19.0 degrees Celsius to 22.0 degrees Celsius. By contrast, the response temperatures of the Raf pathway mutants were within a temperature range of about 20.5 degrees Celsius to 21.5 degrees Celsius (Figures 3B and 3C)."Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005662PATO:0000460Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Phenotype_assayGenotypenjEx359[gcy-8p::GCaMP3, gcy-8p::TagRFP]; n2678 balanced with hT2[qIs48]; Parent strain: IK1776Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
WBPhenotype:0000688Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000698Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001060Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001063Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00005086Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00002087Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00004538Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001061Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00004538Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0001084Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001278Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
Remarkneurons did not show a loss in unc-25::GFP expressionPaper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
ImageWBPicture0000014913Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005027PATO:0000460Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
WBbt:0005021PATO:0000460Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
ReferenceWBPaper00003955
WBPaper00002151
WBPaper00049050
WBPaper00057074
MethodSubstitution_allele