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WormBase Tree Display for Variation: WBVar00090616

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Name Class

WBVar00090616EvidencePaper_evidenceWBPaper00015363
NamePublic_namen2914
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (14)
LaboratoryMT
StatusLive
AffectsGeneWBGene00003026
InteractorWBInteraction000570673
DescriptionPhenotypeWBPhenotype:0000013Paper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
RemarkLarvae homozygous for the lin-41 null allele n2914 rarely entered dauer at the dauer-inducing temperature of 24 degC, in comparison to control larvae that were wild-type forlin-41 or heterozygous for lin-41(0). Only 2/23 (9%) of lin-41(0) homozygous larvae were in dauer. The remaining lin-41(0) larvae had continued development and were in the L3 or L4 stage (Fig. 1A). Therefore, lin-41(0) larvae display a dauer formation-defective (Daf-d) phenotype.Paper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
Phenotype_assayTemperature24 deg CPaper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
Remarklin-41(0) mutants are sterile, and therefore the strain must be propagated as a heterozygote (Slack et al. 2000).Paper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
Phenotype_assayTemperature24 deg CPaper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
WBPhenotype:0001545Paper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
Remark58% of lin-41(0) dauer larvae displayed defective dauer morphology. Specifically, both dauer alae and body shape were abnormal. In contrast to the straight ridges that make up wild-type dauer alae, lin-41(0) mutant dauers displayed wavy dauer alae (Fig. 1C). With respect to body shape, there was a range in severity from worms of a normal length but a somewhat lumpy appearance to Dpy dauers that were shorter and fatter than controls (Fig. 1D).Paper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
Phenotype_assayTemperature24 deg CPaper_evidenceWBPaper00060603
Curator_confirmedWBPerson712
ReferenceWBPaper00015363
WBPaper00060603
MethodAllele