WormBase Tree Display for Variation: WBVar00090616
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WBVar00090616 | Evidence | Paper_evidence | WBPaper00015363 | |||||
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Name | Public_name | n2914 | ||||||
Sequence_details | SeqStatus | Pending_curation | ||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain (14) | ||||||||
Laboratory | MT | |||||||
Status | Live | |||||||
Affects | Gene | WBGene00003026 | ||||||
Interactor | WBInteraction000570673 | |||||||
Description | Phenotype | WBPhenotype:0000013 | Paper_evidence | WBPaper00060603 | ||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Larvae homozygous for the lin-41 null allele n2914 rarely entered dauer at the dauer-inducing temperature of 24 degC, in comparison to control larvae that were wild-type forlin-41 or heterozygous for lin-41(0). Only 2/23 (9%) of lin-41(0) homozygous larvae were in dauer. The remaining lin-41(0) larvae had continued development and were in the L3 or L4 stage (Fig. 1A). Therefore, lin-41(0) larvae display a dauer formation-defective (Daf-d) phenotype. | Paper_evidence | WBPaper00060603 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Temperature | 24 deg C | Paper_evidence | WBPaper00060603 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000688 | Paper_evidence | WBPaper00060603 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | lin-41(0) mutants are sterile, and therefore the strain must be propagated as a heterozygote (Slack et al. 2000). | Paper_evidence | WBPaper00060603 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Temperature | 24 deg C | Paper_evidence | WBPaper00060603 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001545 | Paper_evidence | WBPaper00060603 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | 58% of lin-41(0) dauer larvae displayed defective dauer morphology. Specifically, both dauer alae and body shape were abnormal. In contrast to the straight ridges that make up wild-type dauer alae, lin-41(0) mutant dauers displayed wavy dauer alae (Fig. 1C). With respect to body shape, there was a range in severity from worms of a normal length but a somewhat lumpy appearance to Dpy dauers that were shorter and fatter than controls (Fig. 1D). | Paper_evidence | WBPaper00060603 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Temperature | 24 deg C | Paper_evidence | WBPaper00060603 | ||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00015363 | |||||||
WBPaper00060603 | ||||||||
Method | Allele |