WormBase Tree Display for Variation: WBVar00090996

WBVar00090996 Evidence: Paper_evidence: WBPaper00026736
  Name: Public_name: ne1539
    Other_name: F52F12.3.1:c.463T>C
      CE24994:p.Ser155Pro
    HGVSg: CHROMOSOME_I:g.9899414A>G
  Sequence_details: SMap: S_parent: Sequence: F52F12
    Flanking_sequences: CACATTAATTATACAATTGATCATGTGGCT CATGGATGTTTCAACTATCATCCGCCGTCG
    Mapping_target: F52F12
    Type_of_mutation: Substitution: t c
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00008483
      WBStrain00040428
    Laboratory: WM
    Status: Live
  Affects: Gene: WBGene00003396
    Transcript: F52F12.3.1 VEP_consequence: missense_variant
        VEP_impact: MODERATE
        HGVSc: F52F12.3.1:c.463T>C
        HGVSp: CE24994:p.Ser155Pro
        cDNA_position: 681
        CDS_position: 463
        Protein_position: 155
        Exon_number: 6/13
        Codon_change: Tca/Cca
        Amino_acid_change: S/P
    Interactor: WBInteraction000502190
      WBInteraction000503965
      WBInteraction000503968
      WBInteraction000519777
      WBInteraction000524910
      WBInteraction000541768
      WBInteraction000542277
      WBInteraction000542278
  Isolation: Mutagen: ENU
  Genetics: Interpolated_map_position: I 3.99721
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00026736
        Curator_confirmed: WBPerson2021
        Remark: Mutants have defects in P2/EMS signaling Paper_evidence: WBPaper00026736
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000436 Paper_evidence: WBPaper00026736
        Curator_confirmed: WBPerson2021
        Remark: WRM-1 levels were absent in the E nucleus. The GFP signal was strongly excluded from the nucleus in all cells in the early embryo. This nuclear exclusion was not dependent on IMB-4 Paper_evidence: WBPaper00026736
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0001975 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
            WBbt:0001001 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000071 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
            WBls:0000007 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
            WBls:0000008 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: mom-4 mutants carrying the WRM-1::GFP transgene were examined. Nuclear retention was assayed by subjecting the animals to imb-4 RNAi Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
          Temperature: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
          Genotype: neIs2 [WRM-1::GFP] Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00026736
  Method: Substitution_allele