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WormBase Tree Display for Variation: WBVar00091768

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Name Class

WBVar00091768NamePublic_nameok480
Other_nameT07A9.6.1:c.1518_2370+52del
HGVSgCHROMOSOME_IV:g.421512_422467del
Sequence_detailsSMapS_parentSequenceT07A9
Flanking_sequencesggtgagtagattgaggggtcccgcatataaactggaaatgtgagaacatgttcctcagct
Mapping_targetT07A9
Type_of_mutationDeletion
PCR_productOK480_external
OK480_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000135
WBStrain00031447
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00000913
TranscriptT07A9.6.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScT07A9.6.1:c.1518_2370+52del
cDNA_position1547-?
CDS_position1518-?
Protein_position506-?
Intron_number5-6/8
Exon_number5-6/9
InteractorWBInteraction000518922
WBInteraction000525390
IsolationMutagenUV/TMP
DescriptionPhenotypeWBPhenotype:0000124Paper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
Remarkdaf-18 mutants display decreased activated MAPK expression compared to controlPaper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentStaining with activated MAPK antibodyPaper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
WBPhenotype:0000481Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Remarkdaf-18(ok480) mutant animals display an enhanced aversion response to copper, compared to wild type animals (Figure 2B)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0000823Paper_evidenceWBPaper00027346
Curator_confirmedWBPerson187
Remarkgermline proliferation even when hatched in M9 with or without 0.08% ethanol. (Figure 2)Paper_evidenceWBPaper00027346
Curator_confirmedWBPerson187
Phenotype_assayTreatmentAlso see "Starving Worms to Score Germline Proliferation" in the Supplemental Experimental ProceduresPaper_evidenceWBPaper00027346
Curator_confirmedWBPerson187
WBPhenotype:0001183Paper_evidenceWBPaper00046188
Curator_confirmedWBPerson2987
RemarkFigure 5E, S5BPaper_evidenceWBPaper00046188
Curator_confirmedWBPerson2987
WBPhenotype:0001410Paper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
Remarkdaf-18(ok480) lacked detectable levels of DAF-18/PTEN proteinPaper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentWestern blots with DAF-18 antibodyPaper_evidenceWBPaper00035407
Curator_confirmedWBPerson2021
WBPhenotype:0001999Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkThe integration of signals for attraction to diacetyl (100x dilute) and avoidance from copper (100 millimolar) was impaired in daf-18(ok480) insulin-like signaling pathway mutants, resulting in fewer animals crossing the copper barrier to get to the diacetyl spot than in wild type controls (Figure 1C)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBMol:00002819Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0002256Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
RemarkIncreased sensitivity to movement decline in response to selenium exposure.Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Required for the protective effect of glutathione in selenium exposed animals.Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Affected_byMoleculeWBMol:00001915Paper_evidenceWBPaper00044686
Curator_confirmedWBPerson1754
Phenotype_not_observedWBPhenotype:0000436Paper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
RemarkLocalization of the synaptic protein SNB-1 is normal, based on transgene analysis with a reporter.Paper_evidenceWBPaper00028886
Curator_confirmedWBPerson48
WBPhenotype:0000966Paper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Remarkgermline is immortal at 20 and 25 degrees CelsiusPaper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
Phenotype_assayTreatmentStrains propagated for many generations and checked for sterilityPaper_evidenceWBPaper00028759
Curator_confirmedWBPerson557
WBPhenotype:0001180Paper_evidenceWBPaper00048406
Curator_confirmedWBPerson2987
Remark"... AGE-1 and DAF-18, which produce and hydrolyze PtdIns(3,4,5) P3, respectively, or R01H10.7, an INPP4A homologue that dephosphorylates PtdIns(3,4)P2, are all dispensable for apoptotic cell clearance (Fig S1, R-X)."Paper_evidenceWBPaper00048406
Curator_confirmedWBPerson2987
WBPhenotype:0001470Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkMutants exhibited no change in chemotaxis towards diacetyl, compared to wild type controls (Figure 2A)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkMutant animals exhibit a wild type frequency of body bends (Figure 3A)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Disease_infoModels_diseaseDOID:162
Modifies_diseaseDOID:0080001
Models_disease_in_annotationWBDOannot00001095
Modifies_disease_in_annotationWBDOannot00000565
ReferenceWBPaper00037970
WBPaper00027346
WBPaper00028886
WBPaper00028759
WBPaper00035407
WBPaper00044686
WBPaper00046188
WBPaper00048406
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele