WormBase Tree Display for Variation: WBVar00091907

WBVar00091907 Name: Public_name: ok623
    Other_name: CE47730:p.Met616_Ter845delinsTer
      F07C3.4.1:c.1845_2533delinsCTGAA
    HGVSg: CHROMOSOME_V:g.9236714_9237548delinsTTCAG
  Sequence_details: SMap: S_parent: Sequence: F07C3
    Flanking_sequences: GTCCAAGTTGACCCCATACTCCCCATCCAA ATCTAAAATCTGAATTGTTTTTTTTCTGAT
    Mapping_target: F07C3
    Type_of_mutation: Insertion: ttcag
      Deletion
    PCR_product: OK623_external
      OK623_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005440
      WBStrain00031524
      WBStrain00034033
      WBStrain00034036
      WBStrain00034037
      WBStrain00034043
      WBStrain00034045
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00017195
    Transcript: F07C3.4.1 (11)
    Interactor: WBInteraction000503564
      WBInteraction000518563
      WBInteraction000523986
  Isolation: Mutagen: UV/TMP
  Genetics: Mapping_data: In_multi_point: 5191
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00025094
        Curator_confirmed: WBPerson2021
        Remark: 13-30% embryonic lethal Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00025094
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000054 Paper_evidence: WBPaper00025094
        Curator_confirmed: WBPerson2021
        Remark: 38-57% larval inviablity Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00025094
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000023 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000364 Paper_evidence: WBPaper00025094
        Curator_confirmed: WBPerson2021
        Remark: Embryos accumulated birefringent material extracellularly in the intestinal lumen Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00025094
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with LysoTracker Red and acridine orange Paper_evidence: WBPaper00025094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000625 Paper_evidence: WBPaper00030940
        Curator_confirmed: WBPerson4866
        EQ_annotations: GO_term: GO:0007416 PATO:0000460 Paper_evidence: WBPaper00030940
                Curator_confirmed: WBPerson4866
      WBPhenotype:0000706 Paper_evidence: WBPaper00025094
          WBPaper00041046
        Curator_confirmed: WBPerson2021
          WBPerson2987
        Remark: Embryos lacked gut granules within their intestinal cells. Birefringent material in the intestinal lumen was expelled as newly hatched mutant larvae defecated, and larvae and adult animals had few autofluorescent and acidified gut granules Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00025094
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with LysoTracker Red and acridine orange Paper_evidence: WBPaper00025094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002069 Paper_evidence: WBPaper00040220
          WBPaper00030940
        Curator_confirmed: WBPerson712
          WBPerson4866
        Remark: PLM neurons exhibit overextension as well as terminal hooks. Paper_evidence: WBPaper00040220
            Curator_confirmed: WBPerson712
          PLM neurons exhibit loss of synaptic branching in PLM. Paper_evidence: WBPaper00040220
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005490 PATO:0000460 Paper_evidence: WBPaper00040220
                Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00040220
              Curator_confirmed: WBPerson712
      WBPhenotype:0002469 Paper_evidence: WBPaper00048707
        Curator_confirmed: WBPerson712
        Remark: Mutants had significantly higher habituation levels than wild-type animals, but lower levels than rpm-1 mutants. Paper_evidence: WBPaper00048707
            Curator_confirmed: WBPerson712
        Variation_effect: Loss_of_function_undetermined_extent: Paper_evidence: WBPaper00048707
            Curator_confirmed: WBPerson712
  Reference: WBPaper00040220
    WBPaper00041046
    WBPaper00025094
    WBPaper00028067
    WBPaper00048707
    WBPaper00030940
  Remark: Last updated on 29 Nov 2002
    Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele