WormBase Tree Display for Variation: WBVar00091910

WBVar00091910 Name: Public_name: ok626
    Other_name: T27E9.4a.1:c.-2+300_199-20del
      T27E9.4b.2:c.-2+300_199-20del
    HGVSg: CHROMOSOME_III:g.13465225_13466810del
  Sequence_details: SMap: S_parent: Sequence: T27E9
    Flanking_sequences: acgtcacccgaacaaacagctgagctcaaa accgaaatcaagctttcaggtaatactcgc
    Mapping_target: T27E9
    Type_of_mutation: Deletion
    PCR_product: ok626_external
      ok626_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00031527
      WBStrain00034513
      WBStrain00034555
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00000407
      WBGene00002185
    Transcript: T27E9.3.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2-5/7
        Exon_number: 1-5/8
      T27E9.4a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T27E9.4a.1:c.-2+300_199-20del
        Intron_number: 1-3/12
        Exon_number: 2-3/13
      T27E9.4b.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2/11
        Exon_number: 1-2/12
      T27E9.4b.2 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: T27E9.4b.2:c.-2+300_199-20del
        Intron_number: 1-3/12
        Exon_number: 2-3/13
      T27E9.4a.2 VEP_consequence: splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2/11
        Exon_number: 1-2/12
    Interactor: WBInteraction000502993
      WBInteraction000517467
  Isolation: Mutagen: UV/TMP
  Description: Phenotype: WBPhenotype:0000679 Paper_evidence: WBPaper00030893
        Curator_confirmed: WBPerson48820
        Remark: Quoted from paper: "GLR-1::GFP puncta intensities decreased in both cdk-5(gm336) and cdk-5(ok626) mutants compared with wild-type controls (Figure 2, A-C and E)." Paper_evidence: WBPaper00030893
            Curator_confirmed: WBPerson48820
        Variation_effect: Predicted_null_via_sequence: Paper_evidence: WBPaper00030893
            Curator_confirmed: WBPerson48820
        Phenotype_assay: Genotype: nuIs24[Pglr-1::GLR-1::GFP] Paper_evidence: WBPaper00030893
              Curator_confirmed: WBPerson48820
      WBPhenotype:0001221 Paper_evidence: WBPaper00030893
        Curator_confirmed: WBPerson48820
        Remark: Quoted from paper: "We found that cdk-5 null mutant animals had decreased responses to nose touch compared with wild-type controls (Figure 3I; Student's t test, p < 0.01 for both cdk-5 alleles)." Paper_evidence: WBPaper00030893
            Curator_confirmed: WBPerson48820
        Variation_effect: Predicted_null_via_sequence: Paper_evidence: WBPaper00030893
            Curator_confirmed: WBPerson48820
    Phenotype_not_observed: WBPhenotype:0001588 Paper_evidence: WBPaper00055317
        Curator_confirmed: WBPerson7575
  Reference: WBPaper00055317
    WBPaper00030893
  Remark: Last updated on 29 Nov 2002
    Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele