WormBase Tree Display for Variation: WBVar00092001

WBVar00092001 Name: Public_name: ok719
    HGVSg: CHROMOSOME_III:g.6433128_6433954del
  Sequence_details: SMap: S_parent: Sequence: C05D11
    Flanking_sequences: atctacctttttcacaatttcgtaatcgca gcatggacagccttccagcctcattcacaa
    Mapping_target: C05D11
    Type_of_mutation: Deletion
    PCR_product: ok719_external
      ok719_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00035863
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00006515
      WBGene00006516
    Transcript: C05D11.2.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        cDNA_position: ?-545
        CDS_position: ?-543
        Protein_position: ?-181
        Intron_number: 2-4/11
        Exon_number: 1-5/12
      C05D11.3.1 VEP_consequence: 3_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: 780-?
        Exon_number: 5/5
  Isolation: Mutagen: UV/TMP
  Description: Phenotype: WBPhenotype:0000103 Paper_evidence: WBPaper00025094
        Curator_confirmed: WBPerson2021
        Remark: The embryos of these mutant adults lacked birefringent gut granules Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
        Maternal
        Phenotype_assay: Treatment: Staining with LysoTracker Red and acridine orange Paper_evidence: WBPaper00025094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000241 Paper_evidence: WBPaper00031805
        Curator_confirmed: WBPerson2021
        Remark: Accumulation of refractile apoptotic cells in the gonad in vps-16(ok719) mutants Paper_evidence: WBPaper00031805
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000706 Paper_evidence: WBPaper00028972
          WBPaper00025094
        Curator_confirmed: WBPerson48
          WBPerson2021
        Remark: All of vps-16(ok719) adults had Glo phenotypes with a loss or significant reduction in the number of autofluorescent and acidic gut granules Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with LysoTracker Red and acridine orange Paper_evidence: WBPaper00025094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000867 Paper_evidence: WBPaper00025094
        Curator_confirmed: WBPerson2021
        Remark: The embryos of these mutant adults arrested in early development Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00025094
                Curator_confirmed: WBPerson2021
        Maternal
      WBPhenotype:0001180 Paper_evidence: WBPaper00032272
        Curator_confirmed: WBPerson712
        Remark: A large number of persistent germ-cell corpses were observed. Paper_evidence: WBPaper00032272
            Curator_confirmed: WBPerson712
  Reference: WBPaper00031805
    WBPaper00032272
    WBPaper00025094
    WBPaper00028972
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele