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WormBase Tree Display for Variation: WBVar00092016

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Name Class

WBVar00092016NamePublic_nameok734
Other_nameY76B12C.2.1:c.1575+342_1576-571del
HGVSgCHROMOSOME_IV:g.1997263_1998809del
Sequence_detailsSMapS_parentSequenceY76B12C
Flanking_sequencesaaatgaaaattttcagacatttttgagctgtaatatgatggattacgggaatacaaaacc
Mapping_targetY76B12C
Type_of_mutationDeletion
PCR_productok734_external
ok734_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00031598
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00022296
TranscriptY76B12C.2.1VEP_consequenceintron_variant
VEP_impactMODIFIER
HGVScY76B12C.2.1:c.1575+342_1576-571del
Intron_number4/11
IsolationMutagenUV/TMP
DescriptionPhenotypeWBPhenotype:0001756Paper_evidenceWBPaper00029176
Curator_confirmedWBPerson557
Remarkxpc-1(ok734) mutants showed reduced germ cell apoptosis following UV-C treatment.Paper_evidenceWBPaper00029176
Curator_confirmedWBPerson557
Phenotype_assayTreatmentGerm cell apoptosis was measured following exposure to 100 joules per square meter UV-C.Paper_evidenceWBPaper00029176
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000737Paper_evidenceWBPaper00029176
Curator_confirmedWBPerson557
RemarkAnimals homozygous for the xpc-1(ok734) mutation exhibited normal germ cell apoptosis in response to ionizing radiation.Paper_evidenceWBPaper00029176
Curator_confirmedWBPerson557
Phenotype_assayTreatmentGerm cell apoptosis was measured following exposure to X-rays (120 Gy).Paper_evidenceWBPaper00029176
Curator_confirmedWBPerson557
ReferenceWBPaper00029176
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele