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WormBase Tree Display for Variation: WBVar00092076

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Name Class

WBVar00092076NamePublic_nameok796
Other_nameB0336.2.1:c.149-35_*523delinsCGAAAGAA
B0336.2.2:c.149-35_*523delinsCGAAAGAA
HGVSgCHROMOSOME_III:g.5716302_5717441delinsCGAAAGAA
Sequence_detailsSMapS_parentSequenceB0336
Flanking_sequencesttgggacgtttttttgttgcgaaagaacggctcttctatttcgtatcgaacactgttttg
Mapping_targetB0336
Type_of_mutationInsertionCGAAAGAA
Deletion
PCR_productok796_external
ok796_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00022155
WBStrain00035879
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00000182
TranscriptB0336.2.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScB0336.2.1:c.149-35_*523delinsCGAAAGAA
cDNA_position?-1070
Intron_number2-4/5
Exon_number3-6/6
B0336.2.2VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,3_prime_UTR_variant,intron_variant
VEP_impactHIGH
HGVScB0336.2.2:c.149-35_*523delinsCGAAAGAA
cDNA_position?-1163
Intron_number3-5/6
Exon_number4-7/7
InteractorWBInteraction000500586
WBInteraction000500587
WBInteraction000500591
WBInteraction000502378
WBInteraction000518516
WBInteraction000524009
IsolationMutagenUV/TMP
DescriptionPhenotypeWBPhenotype:0000216Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
RemarkAnimals displayed a weak extra A/PVM phenotype.Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
Phenotype_assayGenotypeayIs9[Pegl-17::gfp]Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
WBPhenotype:0000266Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
RemarkThe cleavage furrow during the QL.p division formed towards the center of the cell rather than at the posterior, creating daughter cells that were closer in size.Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
Phenotype_assayGenotypeayIs9[Pegl-17::gfp]Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
WBPhenotype:0000679Paper_evidenceWBPaper00027612
WBPaper00038432
Curator_confirmedWBPerson712
RemarkCAV-1::GFP co-localizes with Golgi marker SQV-8 in ok796 mutants and not WT as assayed by immunostaining with anti-SQV-8. Authors report identical results with CAV-2::GFP. However, RME-2::GFP localized relatively normally in cytoplasm of oocytes.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Tagged vitellogenin (VIT-2::GFP) accumulated in the pseudocoelom.Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Phenotype_assayTreatmentImmunostained with anti-SQV-8 (generated against aa 150-349)Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
GenotypepwIS281 or pwIs281; RME-2::GFPPaper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
bIs1[Pvit-2::VIT-2::GFP; rol-6(su1006)]Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
WBPhenotype:0001278Paper_evidenceWBPaper00027612
WBPaper00038432
Curator_confirmedWBPerson712
RemarkReduced number of CAV-1 bodies the cytoplasm of ooctyes. Authors report identical results with CAV-2::GFP.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Compared to wild-type oocytes, RME-2::GFP was rarely detected.Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Phenotype_assayGenotypepwIs281Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
bIs1[Pvit-2::VIT-2::GFP; rol-6(su1006)]Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
WBPhenotype:0001323Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
RemarkCAV-1::GFP positive vesicles irregularly shaped. Authors report identical results with CAV-2::GFP.Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
Phenotype_assayGenotypepwIs281Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson712
WBPhenotype:0001425Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
RemarkCompared to wild-type oocytes, fewer arf-1 oocytes contained VIT-2::GFP.Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
Phenotype_assayGenotypebIs1[Pvit-2::VIT-2::GFP; rol-6(su1006)]Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
WBPhenotype:0001585Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
RemarkThe cleavage furrow during the QL.p division formed towards the center of the cell rather than at the posterior, creating daughter cells that were closer in size.Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
Phenotype_assayGenotypeayIs9[Pegl-17::gfp]Paper_evidenceWBPaper00038432
Curator_confirmedWBPerson712
WBPhenotype:0002076Paper_evidenceWBPaper00027612
Curator_confirmedWBPerson3858
Phenotype_not_observedWBPhenotype:0000436Paper_evidenceWBPaper00040857
Curator_confirmedWBPerson712
RemarkMutation did not cause SNB-1::VENUS localization defects.Paper_evidenceWBPaper00040857
Curator_confirmedWBPerson712
WBPhenotype:0001652Paper_evidenceWBPaper00032446
Curator_confirmedWBPerson2021
ReferenceWBPaper00038432
WBPaper00040857
WBPaper00032446
WBPaper00027612
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele