WormBase Tree Display for Variation: WBVar00092473

WBVar00092473 Evidence: Paper_evidence: WBPaper00038354
  Name: Public_name: ok1221
    HGVSg: CHROMOSOME_II:g.4324028_4325074del
  Sequence_details: SMap: S_parent: Sequence: H20J04
    Flanking_sequences: gaaacagcatttatttcagccgaaacagtt cgaaaaattttaagccatttttcgaaaaat
    Mapping_target: H20J04
    Type_of_mutation: Deletion
    PCR_product: ok1221_external
      ok1221_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00036069
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00019221
      WBGene00003390
    Transcript: H20J04.6.1 VEP_consequence: 3_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: 623-?
        Exon_number: 6/6
      H20J04.8.1 VEP_consequence: splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2/3
        Exon_number: 1-2/4
    Interactor: WBInteraction000501293
  Isolation: Mutagen: UV/TMP
  Genetics: Mapping_data: In_multi_point: 5349
  Description: Phenotype: WBPhenotype:0000031 Paper_evidence: WBPaper00038354
        Curator_confirmed: WBPerson712
        Remark: Mog-2 alleles grew significantly slower than wild type siblings at 15 deg C and 20 deg C. Furthermore, mog-2(q75) larvae required more time to develop into adults than mog-2(ok1221). Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 20, 25 Paper_evidence: WBPaper00038354
              Curator_confirmed: WBPerson712
      WBPhenotype:0000052 Paper_evidence: WBPaper00038354
        Curator_confirmed: WBPerson712
        Remark: At 25 deg C, 100% of the progeny of homozygous mog-2 mutants died as embryos, without showing signs of morphogenesis. Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 20, 25 Paper_evidence: WBPaper00038354
              Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
      WBPhenotype:0000683 Paper_evidence: WBPaper00038354
        Curator_confirmed: WBPerson712
        Remark: Hermaphrodites developed as somatic females that made excess of sperm and no oocytes. At 25 deg C, most germ lines are fully masculinized. Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 20, 25 Paper_evidence: WBPaper00038354
              Curator_confirmed: WBPerson712
      WBPhenotype:0001369 Paper_evidence: WBPaper00038354
        Curator_confirmed: WBPerson712
        Remark: U2 snRNA was not coimmunoprecipitated in the absence of MOG-2 in a mog-2(ok1221) null mutant. Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000508 Paper_evidence: WBPaper00038354
        Curator_confirmed: WBPerson712
        Remark: While an alternatively spliced variant of the rpl-7A was detected in smg-1 and smg-1; mog-2 mutants, it was observed neither in wild type, nor in mog-2 animals. Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038354
            Curator_confirmed: WBPerson712
  Reference: WBPaper00038354
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele