WormBase Tree Display for Variation: WBVar00092602

WBVar00092602 Evidence: Person_evidence: WBPerson2969
  Name: Public_name: ok1387
    Other_name: C48C5.1.1:c.508-235_857-277del
    HGVSg: CHROMOSOME_X:g.8982345_8983585del
  Sequence_details: SMap: S_parent: Sequence: C48C5
    Flanking_sequences: tttaagaaaacaccacttgaaaaacgcaga agtctagtggtctagtgaaccagtttgcaa
    Mapping_target: C48C5
    Type_of_mutation: Deletion
    PCR_product: OK1387_external
      OK1387_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00031987
    Laboratory: RB
    Person: WBPerson46
      WBPerson2969
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00016747
    Transcript: C48C5.1.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: C48C5.1.1:c.508-235_857-277del
        Intron_number: 4-8/11
        Exon_number: 5-8/12
  Description: Phenotype: WBPhenotype:0001014 Paper_evidence: WBPaper00032196
        Curator_confirmed: WBPerson712
        Remark: Animals were less susceptible to infection by P. aeruginosa than N2 animals due to significant differences (p<0.0001) in survival compared to wild type in two independent experiments using PRISM to apply a logrank test. Paper_evidence: WBPaper00032196
            Curator_confirmed: WBPerson712
        Phenotype_assay: Strain: WBStrain00031987 Paper_evidence: WBPaper00032196
              Curator_confirmed: WBPerson712
      WBPhenotype:0002598 Paper_evidence: WBPaper00059641
        Curator_confirmed: WBPerson10038
        Remark: Quote from paper: "Similar to classical aversive conditioning, we trained worms by pairing a conditioned salt stimulus with the absence of food during a 15-min training period (Fig. 1c). We then tested salt chemotaxis behavior... Consistent with our hypothesis, nmur-1 mutants were defective in learning and still attracted to salt after NaCl-conditioning (Fig.1d)." Paper_evidence: WBPaper00059641
            Curator_confirmed: WBPerson10038
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00059641
              Curator_confirmed: WBPerson10038
  Reference: WBPaper00032196
    WBPaper00059641
  Remark: Allele sequenced by Neline Kriek Curator_confirmed: WBPerson2970
    Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele