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WormBase Tree Display for Variation: WBVar00092724

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Name Class

WBVar00092724NamePublic_nameok1513
Other_nameY42H9AR.3a.1:c.109_1503-60del
Y42H9AR.3b.1:c.109_1503-54del
HGVSgCHROMOSOME_IV:g.8104730_8107114del
Sequence_detailsSMapS_parentSequenceY42H9AR
Flanking_sequencesgcgaattcacttcaagaaaggcgtagctatgagtcgttcgtattctccaaagtcttccat
Mapping_targetY42H9AR
Type_of_mutationDeletion
PCR_productok1513_external
ok1513_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00036301
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00021538
TranscriptY42H9AR.3a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScY42H9AR.3a.1:c.109_1503-60del
cDNA_position113-?
CDS_position109-?
Protein_position37-?
Intron_number3-7/8
Exon_number3-7/9
Y42H9AR.3b.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScY42H9AR.3b.1:c.109_1503-54del
cDNA_position111-?
CDS_position109-?
Protein_position37-?
Intron_number3-7/8
Exon_number3-7/9
IsolationMutagenUV/TMP
GeneticsMapping_dataIn_multi_point5613
DescriptionPhenotypeWBPhenotype:0001425Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
RemarkAnimals were indistinguishable from vsp-45 mutants for this phenotype.Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
Phenotype_assayTemperature15, 25Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
Genotypevitellogenin::EGFP (YP170/EGFP)Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
WBPhenotype:0001426Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
RemarkAnimals were indistinguishable from vsp-45 mutants for this phenotype.Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005751PATO:0000460Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
Phenotype_assayTemperature15, 25Paper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
GenotypePmyo-3::ssGFPPaper_evidenceWBPaper00029049
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000256Paper_evidenceWBPaper00048972
Curator_confirmedWBPerson2987
Remark"Third, the mammalian homologue of PMK-3, p38 MAPK, was shown to accelerate Rab5-mediated endocytosis by phosphorylating and activating GDI [34, 41, 42]. In addition, p38 MAPK regulates endocytosis by phosphorylating the Rab5 effector proteins EEA1 (EEA-1 in C_elegans) and Rabenosyn-5 (RABS-5) involved in tethering/docking and fusion of endosomes [35]. Neither eea-1(tm9033) [sic] or rabs-5(ok1513) suppressed the dye-filling defect of gpa-3QL (gjEx862) (Fig 5B)."Paper_evidenceWBPaper00048972
Curator_confirmedWBPerson2987
Phenotype_assayGenotypegpa-3QL(gjEx862)Paper_evidenceWBPaper00048972
Curator_confirmedWBPerson2987
WBPhenotype:0010004Paper_evidenceWBPaper00031805
Curator_confirmedWBPerson2021
RemarkDisruption of the FYVE-domain-containing proteins did not cause obvious defects in corpse removal in the germ linePaper_evidenceWBPaper00031805
Curator_confirmedWBPerson2021
ReferenceWBPaper00031805
WBPaper00029049
WBPaper00048972
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele