WormBase Tree Display for Variation: WBVar00093080

WBVar00093080 Evidence: Paper_evidence: WBPaper00033073
  Name: Public_name: ok1884
    Other_name: R186.5c.1:c.45-299_439-259del
      R186.5a.2:c.-10-299_385-259del
      R186.5b.1:c.54-299_448-259del
      R186.5a.1:c.-10-299_385-259del
    HGVSg: CHROMOSOME_V:g.12975529_12976640del
  Sequence_details: SMap: S_parent: Sequence: R186
    Flanking_sequences: aaactttaaaatgaagcttcaaaatttcaa tcactttggagtcgactacggtaggaggag
    Mapping_target: R186
    Type_of_mutation: Deletion
    PCR_product: ok1884_external
      ok1884_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00032252
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00201025
      WBGene00004793
    Transcript: R186.13 VEP_consequence: transcript_ablation
        VEP_impact: HIGH
        Exon_number: 1/1
      R186.5a.3 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2-5/10
        Exon_number: 1-5/11
      R186.5c.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: R186.5c.1:c.45-299_439-259del
        Intron_number: 1-5/9
        Exon_number: 2-5/10
      R186.5b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: R186.5b.1:c.54-299_448-259del
        Intron_number: 1-5/9
        Exon_number: 2-5/10
      R186.5a.2 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: R186.5a.2:c.-10-299_385-259del
        Intron_number: 1-6/11
        Exon_number: 2-6/12
      R186.5a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: R186.5a.1:c.-10-299_385-259del
        Intron_number: 1-6/11
        Exon_number: 2-6/12
  Isolation: Mutagen: UV/TMP
  Description: Phenotype: WBPhenotype:0000316 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: Mutants do not respond to touch on the tail Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001221 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: Mutants do not respond to touch on the head Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001315 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: Genetic ablation of kht-1 results in decreased K+ flux compared to N2 Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001316 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: In kht-1 nulls, currents inactivated with peak values roughly 20% smaller than those of the N2 current. The steady-state component of the current was markedly diminished Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
      WBPhenotype:0002469 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: During habituation attempts, animals were less receptive to taps than normal worms, as though they were already desensitized Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000816 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: Null mutants did not show developmental or morphological abnormalities in neurons Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000905 Paper_evidence: WBPaper00033073
        Curator_confirmed: WBPerson2021
        Remark: Null mutants did not show developmental or morphological abnormalities in neurons Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00033073
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00033073
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele