WormBase Tree Display for Variation: WBVar00093368

WBVar00093368 Evidence: Paper_evidence: WBPaper00034719
  Name: Public_name: ok2204
    HGVSg: CHROMOSOME_III:g.10114979_10115951del
  Sequence_details: SMap: S_parent: Sequence: ZK1128
    Flanking_sequences: acatataatatgtgtcgtttcctcgtctat aatatttatatgaatattatacagcatttc
    Mapping_target: ZK1128
    Type_of_mutation: Deletion
    PCR_product: ok2204_external
      ok2204_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00036838
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00014228
    Transcript: ZK1128.2b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 1-4/5
        Exon_number: 1-4/6
      ZK1128.2a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,5_prime_UTR_variant,intron_variant
        VEP_impact: HIGH
        Intron_number: 2-4/6
        Exon_number: 1-4/7
  Isolation: Mutagen: EMS
  Description: Phenotype: WBPhenotype:0000052 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10 animals are Mel Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
        Maternal
      WBPhenotype:0000085 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10 animals exhibit distension of the intestinal lumen Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000688 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10 animals are sterile (Ste) Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000697 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, mett-10 animals are Pvl Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000866 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At all temperatures, the proliferative zone of mett-10(ok2204) germ lines contain enlarged, diffuse nuclei that arrest at some point other than M phase (not pH3-positive, non EdU labeled) Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001033 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: Many germ lines contain pachytene cells in the proximal-most region of the germ line (This region is normally occupied by diakinetic oocytes in wild-type). Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001348 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: Abnormal chromosomal morphology is visible in mett-10 nulls Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001355 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: At 25C, 30% of mett-10(ok2204) germ lines have at least one extra protrusion in the distal gonad Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001668 Paper_evidence: WBPaper00034719
        Curator_confirmed: WBPerson2021
        Remark: In situations where proximal mett-10(ok2204) germ cells progress from pachytene to diplotene, there is often disruption of normal linear oocyte organization. abnormal chromosomal morphology are visible in mett-10 nulls Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00034719
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00034719
            Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00034719
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002119 Paper_evidence: WBPaper00061521
        Curator_confirmed: WBPerson1686
  Reference: WBPaper00034719
    WBPaper00061521
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele