WormBase Tree Display for Variation: WBVar00093393

WBVar00093393 Name: Public_name: ok2229
    Other_name: Y67A10A.8b.1:c.343-43_796delinsA
      Y67A10A.8a.1:c.481-43_934delinsA
    HGVSg: CHROMOSOME_IV:g.14380184_14381705delinsT
  Sequence_details: SMap: S_parent: Sequence: Y67A10A
    Flanking_sequences: aattggaattgactgaagaagaagagattt cactaaaatgtttacaatttttgtgtttct
    Mapping_target: Y67A10A
    Type_of_mutation: Insertion: T
      Deletion
    PCR_product: ok2229_external
      ok2229_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00031176
      WBStrain00032435
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00170763
      WBGene00164999
      WBGene00172726
      WBGene00013457
      WBGene00049818
      WBGene00046184
    Transcript: Y67A10A.296
      Y67A10A.8b.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y67A10A.8b.1:c.343-43_796delinsA
        cDNA_position: ?-796
        CDS_position: ?-796
        Protein_position: ?-266
        Intron_number: 2-5/5
        Exon_number: 3-6/6
      Y67A10A.146
      Y67A10A.32
      Y67A10A.119
      Y67A10A.8a.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: Y67A10A.8a.1:c.481-43_934delinsA
        cDNA_position: ?-936
        CDS_position: ?-934
        Protein_position: ?-312
        Intron_number: 4-7/8
        Exon_number: 5-8/9
      Y67A10A.256
    Interactor: WBInteraction000535440
      WBInteraction000535454
      WBInteraction000535456
      WBInteraction000535458
      WBInteraction000535459
      WBInteraction000535460
  Isolation: Mutagen: EMS
  Description: Phenotype: WBPhenotype:0000154 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
      WBPhenotype:0001213 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: speed of locomotion is slower than wild type animals Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
      WBPhenotype:0001485 Paper_evidence: WBPaper00051473
        Curator_confirmed: WBPerson38423
        Remark: more sensitive to conditions ER stress induced by tunicamycin (figure 1A and supplementary figure S1) Paper_evidence: WBPaper00051473
            Curator_confirmed: WBPerson38423
        Phenotype_assay: Strain: WBStrain00031176 Paper_evidence: WBPaper00051473
              Curator_confirmed: WBPerson38423
          Control_strain: WBStrain00000001 Paper_evidence: WBPaper00051473
              Curator_confirmed: WBPerson38423
    Phenotype_not_observed: WBPhenotype:0000032 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: mutants are healthy Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
      WBPhenotype:0000073 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
      WBPhenotype:0000138 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: none of the single mutants showed a significant difference in their lipid content compared to wild type Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: daf-2(e1370) Paper_evidence: WBPaper00039827
              Curator_confirmed: WBPerson712
      WBPhenotype:0000145 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: mutants made it to 100% fertile adults at all temperatures Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
      WBPhenotype:0000308 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: animals do not show any defects in entry or exit from dauer Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: daf-2(e1370) Paper_evidence: WBPaper00039827
              Curator_confirmed: WBPerson712
      WBPhenotype:0000725 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: fatty acid composition is not different from wt Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
      WBPhenotype:0001453 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: animals do not show any defects in high osmolarity avoidance behavior Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00039827
              Curator_confirmed: WBPerson712
      WBPhenotype:0001472 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00001063 Paper_evidence: WBPaper00039827
              Curator_confirmed: WBPerson712
      WBPhenotype:0001888 Paper_evidence: WBPaper00039827
        Curator_confirmed: WBPerson712
        Remark: lipid droplet size was not different than wt Paper_evidence: WBPaper00039827
            Curator_confirmed: WBPerson712
  Reference: WBPaper00039827
    WBPaper00051473
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele