WormBase Tree Display for Variation: WBVar00093812

WBVar00093812 Evidence: Paper_evidence: WBPaper00038379
  Name: Public_name: ok2710
    Other_name: Y113G7B.17.2:c.22_499del
      CE23297:p.Ser8CysfsTer63
      Y113G7B.17.1:c.22_499del
    HGVSg: CHROMOSOME_V:g.20269152_20269683del
  Sequence_details: SMap: S_parent: Sequence: Y113G7B
    Flanking_sequences: cgtagagacgagccttgtccgggaacaaca cttcccgttttcggtactcattgtcccgct
    Mapping_target: Y113G7B
    Type_of_mutation: Deletion
    PCR_product: ok2710_external
      ok2710_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00032731
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00013766
    Transcript: Y113G7B.17.1 (11)
      Y113G7B.17.2 (11)
    Interactor (11)
  Isolation: Mutagen: EMS
  Description: Phenotype: WBPhenotype:0000031 Paper_evidence: WBPaper00038379
        Curator_confirmed: WBPerson712
        Remark: Mutants are apparently normal in embryonic and larval development, except for a slight slow growth (data not shown). Paper_evidence: WBPaper00038379
            Curator_confirmed: WBPerson712
      WBPhenotype:0000134 Paper_evidence: WBPaper00038379
        Curator_confirmed: WBPerson712
        Remark: Loss of prmt-1 resulted in an approximately 50% reduction in the expression of sod-3 and mtl-1, and a 70% reduction in that of sip-1 and lys-7. Paper_evidence: WBPaper00038379
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 22.5 Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: Is[daf-16::gfp] Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00038379
        Curator_confirmed: WBPerson712
        Remark: Compared with controls, Is[daf-16::gfp];prmt-1 animals showed a significant decrease in the proportion of nuclear DAF-16::GFP when worms were starved for 6 hr and 12 hr. Paper_evidence: WBPaper00038379
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 22.5 Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: Is[daf-16::gfp] Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
      WBPhenotype:0001171 Paper_evidence: WBPaper00038379
        Curator_confirmed: WBPerson712
        Remark: Loss of prmt-1 resulted in a statistically significant decrease in life span compared with wild-type worms. Paper_evidence: WBPaper00038379
            Curator_confirmed: WBPerson712
        Rescued_by_transgene: WBTransgene00015541
          WBTransgene00015548
      WBPhenotype:0001350 Paper_evidence: WBPaper00038379
        Curator_confirmed: WBPerson712
        Remark: Loss of prmt-1 in the Is[daf-16::gfp] background led to a marked increase in the intensity of phosphorylated DAF-16 compared with Is[daf-16::gfp] controls. Paper_evidence: WBPaper00038379
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 22.5 Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: Is[daf-16::gfp] Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
      WBPhenotype:0001370 Paper_evidence: WBPaper00038379
        Curator_confirmed: WBPerson712
        Remark: DAF-16 in the prmt-1(ok2710) background bound to 14-3-3 protein to a greater extent than did the controls. Paper_evidence: WBPaper00038379
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 22.5 Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: Is[daf-16::gfp] Paper_evidence: WBPaper00038379
              Curator_confirmed: WBPerson712
      WBPhenotype:0001382 Paper_evidence: WBPaper00050741
        Curator_confirmed: WBPerson14716
        Remark: Animals exhibit different levels of methylarginine protein modifications Paper_evidence: WBPaper00050741
            Curator_confirmed: WBPerson14716
      WBPhenotype:0001575 Paper_evidence: WBPaper00050551
        Curator_confirmed: WBPerson12101
        Remark: Loss of prmt-1 causes impaired ATP synthesis in mitochondria (Figure S2) Paper_evidence: WBPaper00050551
            Curator_confirmed: WBPerson12101
        EQ_annotations: GO_term: GO:1905447 PATO:0000460 Paper_evidence: WBPaper00050551
                Curator_confirmed: WBPerson12101
            GO:0005739 PATO:0000460 Paper_evidence: WBPaper00050551
                Curator_confirmed: WBPerson12101
  Reference: WBPaper00038379
    WBPaper00050551
    WBPaper00050741
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele